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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent ne…

Oberst(Andrew),Dillon(Christopher P),Weinlic… Nature 2011-04-06

...CFLAR), and this complex is required for the protective function.

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

Bivona(Trever G),Hieronymus(Haley),Parker(Jo… Nature 2011-05-02

...CFLAR and IKBKB, respectively), or silencing of IκB (also known as NFKBIA), rescued EGFR-mutant lung cancer cells from E...

Multigene expression-based predictors for sensitivity to Vorinostat and Velcade…

Nagji(Alykhan S),Cho(Sang-Hoon),Liu(Yuan),Le… Mol Cancer Ther 2011-03-10

...CFLAR). Examination of Vorinostat gene ontogeny revealed a predilection for cellular replication and death, whereas that...

Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrom…

Roberts(Aedan),Nancarrow(Derek),Clendenning(… Fam Cancer 2011-10-03

...CFLAR, CASP10, CASP8, FZD7 and BMPR2) were sequenced and no segregating variants identified. There was no evidence of li...

Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+…

Ulasov(Ilya V),Nandi(Suvobroto),Dey(Mahua),S… Mol Med 2011-11-04

...CFLAR downregulation (4.22-fold). The therapeutic effect of TMZ was enhanced by Notch and SHH pathway pharmacological an...

Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmac…

Lepelletier(Yves),Zollinger(Raphaël),Ghirell… Blood 2010-12-15

...CFLAR) versus proapoptotic genes (Caspase-8, BID, BAD, BAX). In particular, virus-induced Bcl-2 up-regulation was depend...

Global DNA methylation in fetal human germ cells and germ cell tumours: associa…

Wermann(Hendrik),Stoop(Hans),Gillis(Ad J M),… J Pathol 2010-08-02

...CFLAR, a gene previously described in treatment resistance in GCTs.

Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquiti…

Chandrasekaran(Yamini),McKee(Chad M),Ye(Yang… Biol Reprod 2010-03-16

...Cflar resulted in reduction of CFLAR (L) protein levels and increased sensitivity to JO2-mediated apoptosis. The CFLAR (...

FasL gene-deficient mice display a limited disruption in spermatogenesis and in…

Lin(Yi-Chen),Yao(Pei-Li),Richburg(John H) Toxicol Sci 2010-06-21

...CFLAR (c-FLIP) protein, a known inhibitor of death receptor signaling. In contrast, MEHP treatment did not decrease c-FL...

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgeho…

Katoh(Y),Katoh(M) Curr Mol Med 2010-01-04

...CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin. Hedgehog signals are fine-tuned based on positive fee...

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