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Liquid-Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular…

Thakur(DK),Padole(S),Sarkar(T),Arumugam(S),C… FASEB Bioadv 2025-11-00

...SPOP and YAP/TAZ proteins, and viral infections where pathogens use LLPS to replicate and avoid immune detection. This r...

Next-generation sequencing technology in prostate cancer diagnosis, prognosis, …

Yadav(Shalini S),Li(Jinyi),Lavery(Hugh J),Ya… Urol Oncol 2016-02-24

...SPOP and CHD1 mutations, and chromoplexy), and many previous ones in well-established pathways have been validated (e.g....

Speckle-type POZ protein is negatively associated with malignancies and inhibit…

Huang(Yuping),Tan(Ning),Jia(Deshui),Jing(Yin… Tumour Biol 2016-04-26

...SPOP in hepatocellular carcinoma (HCC) remain unknown. In this study, we found that the expression level of SPOP was dow...

Properties and Clinical Relevance of Speckle-Type POZ Protein in Human Colorect…

Xu(Junfei),Wang(Feiran),Jiang(Haiyan),Jiang(… J Gastrointest Surg 2016-03-16

...SPOP low expression group and SPOP high expression group. Correlation of survival with clinicopathologic parameters, inc...

Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins.

Shin(Yeong Ju),Park(Seung Kyun),Jung(Yoo Jun… Sci Rep 2016-08-19

...SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rapid ubiquitination and subsequen...

SPOP mutation leads to genomic instability in prostate cancer.

Boysen(Gunther),Barbieri(Christopher E),Pran… Elife 2016-06-07

...SPOP mutation is associated with genomic instability. In vivo, SPOP mutation results in a transcriptional response consi...

Clustering of pelvic floor disorders 20 years after one vaginal or one cesarean…

Gyhagen(Maria),Åkervall(Sigvard),Milsom(Ian) Int Urogynecol J 2016-04-15

...sPOP), and fecal incontinence (FI), 20 years after one vaginal (VD) or one cesarean (CS) delivery.,We carried out a regi...

Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.

Ji(Alan X),Chu(Anh),Nielsen(Tine Kragh),Benl… J Mol Biol 2016-06-06

...SPOP in complex with the N-terminal domain of Cul3 revealed the features required for Cul3 recognition in these proteins...

Association between pelvic floor muscle trauma and pelvic organ prolapse 20 yea…

Volløyhaug(Ingrid),Mørkved(Siv),Salvesen(Kje… Int Urogynecol J 2016-11-01

...sPOP) and signs (POP-Q ≥2) in patient populations. Our aims were to establish the prevalence and investigate a possible ...

Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Can…

Zhao(Junfei),Cheng(Feixiong),Wang(Yuanyuan),… Mol Cell Proteomics 2016-10-21

...SPOP and NR3C1). Furthermore, our integrative analysis indicated that 13% of patients might benefit from current targete...

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