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STAT3 modulates cigarette smoke-induced inflammation and protease expression.

Geraghty(Patrick),Wyman(Anne E),Garcia-Arc... Front Physiol 2013-10-08

...SOCS3 and IL-10 were markedly lower in the STAT3(-/-) mice compared to the STAT3(+/+) mice. Lastly, apoptosis, as determ...

Inhibition of microRNA122 decreases SREBP1 expression by modulating suppresso...

Shibata(Chikako),Kishikawa(Takahiro),Otsuk... Biochem Biophys Res Commun 2013-11-04

...SOCS3) expression, and because we previously found that SOCS3 expression is regulated by miR122, in this study, we exami...

IL-18 induces profibrotic renal tubular cell injury via STAT3 activation.

Matsui(Futoshi),Rhee(Audrey),Hile(Karen L)... Am J Physiol Renal Physiol 2013-12-11

...SOCS3 expression increased significantly in response to obstruction; however, a significant reduction in p-STAT3 and SOC...

Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequest...

Reitsma(Justin M),Sato(Hiromi),Nevels(Mich... J Virol 2013-12-27

...SOCS3 promoter, and SOCS3 gene expression. Finally, inhibition of STAT3 nuclear localization or STAT3 expression during ...

SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication.

Shao(Run-Xuan),Zhang(Leiliang),Hong(Zhi),G... Antiviral Res 2013-07-08

...SOCS3) have been thought to block type I interferon (IFN) signaling. We have previously reported that SOCS3 suppresses H...

IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and progra...

Liu(Zhenzhen),Liu(Jin-Qing),Talebian(Fatem... Eur J Immunol 2013-07-01

...SOCS3, Sca-1, and IL-10. While STAT3 activation and the CTL survival-enhancing effects can be independent of CTL IL-10 p...

The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferatio...

Ray(Sutapa),Ju(Xiaoxi),Sun(Hong),Finnerty(... J Invest Dermatol 2013-07-09

...SOCS3, was upregulated in HSFs and showed increased STAT3 binding on its promoter relative to NFs in a chromatin immunop...

[Expression of SOCS3 and Pyk2 and their correlation in non-small cell lung ca...

Zhang(Si-yang),Qiu(Xue-shan) Zhonghua Bing Li Xue Za Zhi 2013-04-29

...SOCS3 and Pyk2 in both NSCLC tissues and cell lines. SOCS3 was aberrantly methylated and 5-aza restored SOCS3 expression...

Detection of endogenous SOCS1 and SOCS3 proteins by immunoprecipitation and W...

Zhang(Jian-Guo),Nicholson(Sandra E) Methods Mol Biol 2013-06-11

The suppressors of cytokine signalling (SOCS) protein family consist of eight members (SOCS 1-7, and CIS). SOCS1 and SOC...

Overexpression of SOCS3 in T lymphocytes leads to impaired interleukin-17 pro...

Romain(Mélissa),Taleb(Soraya),Dalloz(Mario... Arterioscler Thromb Vasc Bi... 2013-04-10

...SOCS3 in bone marrow-derived cells significantly increased aneurysm severity (P=0.04). In contrast, overexpression of SO...

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