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Cathepsin L inactivation leads to multimodal inhibition of prostate cancer ce...

Sudhan(Dhivya R),Pampo(Christine),Rice(Lor... Int J Cancer 2016-08-03

...CTSL) to metastatic dissemination of cancer cells has led to the development of several CTSL inhibition strategies. The ...

Activated cathepsin L is associated with the switch from autophagy to apoptot...

Li(Lingyun),Gao(Luyan),Song(Yunzhen),Qin(Z... Biochem Biophys Res Commun 2016-06-14

...CTSL). The CTSL inhibitor, Z-FY-CHO, could promote autophagy, decrease accumulation of P62, and block activation of casp...

An integrative systems genetics approach reveals potential causal genes and p...

Kogelman(Lisette J A),Zhernakova(Daria V),... Genome Med 2016-05-19

...CTSL, and ABHD12B.,To our knowledge, this is the first study to perform an integrated genomics and transcriptomics (eQTL...

Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune ...

Gonzalez-Leal(Iris J),Röger(Bianca),Schwar... PLoS Negl Trop Dis 2016-01-22

...Ctsl-/- mice, and studied the effects of Ctsb and Ctsl deficiency on the survival of L. major in infected cells. Further...

Gene expression profiles of peripheral blood mononuclear cells in primary bi...

Zhang(Lei),Ma(Danxu),Li(Xi),Deng(Chuiwen),... Clin Exp Med 2015-06-23

...CTSL) were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) in a second Cohort 2 (30 PBC patients...

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.

McGlinchey(Ryan P),Lee(Jennifer C) Proc Natl Acad Sci U S A 2015-10-27

...CtsL). Both CtsB and CtsL cleave α-syn within its amyloid region and circumvent fibril formation. For CtsD, only in the ...

Diabetes-induced alterations in tissue collagen and carboxymethyllysine in ra...

Brings(Sebastian),Zhang(Shaoping),Choong(Y... Biochim Biophys Acta 2015-09-11

...CTSL) and matrix metalloproteinase-2 (MMP-2) were increased in diabetic rats. CTSL-levels correlated strongly and positi...

Protease inhibitors targeting coronavirus and filovirus entry.

Zhou(Yanchen),Vedantham(Punitha),Lu(Kai),A... Antiviral Res 2015-12-15

...CTSL) and cathepsin B (CTSB). In addition, SARS- and MERS-coronavirus can use serine proteases localized at the cell sur...

Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression...

Tholen(Martina),Wolanski(Julia),Stolze(Bri... J Biol Chem 2015-08-28

...CTSL activity in various tumor entities; however, the mechanisms leading to high CTSL levels are incompletely understood...

[THE GENETIC DIVERSITY OF PIG BREEDS ON TEN PRODUCTION QUANTITATIVE TRAITS LO...

Balatskyi(V N),Saienko(A M),Pena(R N),Busl... Tsitol Genet 2015-12-29

...CTSL, CTSS, CTSB, CTSK, MC4R, ESR1 & PRLR was analyzed. The results allow us to suppose that the uniqueness of genetic s...

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