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Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid ...

Krishnamurthy(Pavan K),Rajamohamedsait(Ham... Front Endocrinol (Lausanne) 2016-07-06

...IAPP or IAPP7-19-TT treatments had no effect on glucose clearance in Tg males. Overall, these beneficial effects of IAPP...

Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical spec...

Fortin(Jessica S),Benoit-Biancamano(Marie-... Amyloid 2016-05-18

...IAPP) amyloidogenicity is quite variable among animal species, and studying this variability could further our understan...

Is there a role for the adaptive immune system in pancreatic beta cell failur...

Westwell-Roper(Clara),Ehses(Jan A) Diabetologia 2015-04-15

...IAPP). In this issue of Diabetologia, Butcher et al have further characterised immune cell subsets present in islets fro...

High plasma levels of islet amyloid polypeptide in young with new-onset of ty...

Paulsson(Johan F),Ludvigsson(Johnny),Carls... PLoS One 2015-06-01

...IAPP might increase the risk for IAPP misfolding and formation of cell toxic amyloid in beta cells. This finding add IAP...

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutraliz...

Bram(Yaron),Frydman-Marom(Anat),Yanai(Inba... Sci Rep 2015-10-09

...IAPP peptide can form highly toxic oligomers. The presence of antibodies identified in the serum of diabetic patients co...

Structure based aggregation studies reveal the presence of helix-rich interme...

Ghosh(Dhiman),Singh(Pradeep K),Sahay(Shrut... Sci Rep 2015-12-14

...IAPP, we hypothesize that this class of intermediates may be one of the important intermediates for amyloid formation pa...

Islet amyloid polypeptide exerts a novel autocrine action in β-cell signaling...

Visa(Montse),Alcarraz-Vizán(Gema),Montane(... FASEB J 2015-09-14

...IAPP on β cells. We show that IAPP activated Erk1/2 and v-akt murine thymoma viral oncogene homolog 1 (Akt) at the picom...

Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and I...

Oskarsson(Marie E),Singh(Kailash),Wang(Jia... J Biol Chem 2015-09-10

...IAPP) that overexpresses human heparanase and human IAPP but is deficient of endogenous mouse IAPP. Culture of hpa-hIAPP...

The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Sug...

Andrich(Kathrin),Bieschke(Jan) Adv Exp Med Biol 2015-10-02

...IAPP), Sup35, NM25 and NM4, tau, MSP2, semen-derived enhancer of virus infection (SEVI), immunoglobulin light chains, be...

Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacolog...

Nath(Abhinav),Schlamadinger(Diana E),Rhoad... Biochemistry 2015-08-21

...IAPP) is a peptide hormone whose pathological self-assembly is a hallmark of the progression of type II diabetes. IAPP-m...

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