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Reticuline alleviates rheumatoid arthritis by suppressing the JAK/STAT signal...

Tian(J),Zhang(J),Yang(Y),Song(Y),Yuan(Z),C... Clin Rheumatol 2026-09-00

...JAK2, forming five hydrogen bonds. In TNF‑α‑stimulated human synovial fibroblasts (MH7A), reticuline (10 and 20 µM) sign...

SLAMF8 promotes tumor growth of gastric cancer by enhancing M2 polarization o...

Wu(Y),Zhang(X),Tang(Z),Li(F),Wu(L),Zhou(H) J Transl Med 2026-05-16

...JAK2/STAT3 signaling pathway. Furthermore, SLAMF8-overexpressing TAMs enhanced the growth of MKN-45 cells both in vitro ...

Altered phenotype and gene expression of regulatory T cells (Tregs) in childr...

Moreno(RJ),Rose(D),Ashwood(P) J Neuroinflammation 2026-02-17

...JAK2, and CASP3) was also noted in ASD Tregs. Downregulated DEGs consisted of genes enriched in immune terms including t...

From essential thrombocythemia to polycythemia vera (ET-2-PV): rationale and ...

Barbui(T),Thiele(J),Alvarez-Larran(A),Ramb... Ann Hematol 2026-03-04

...JAK2V617F mutation, suggesting a biological continuum. Occasional reports describe progression from JAK2-mutated ET to o...

In-silico prediction of multi‑target mechanisms of Pinellia ternata phytochem...

Bian(G),Zhang(Y),Shen(Y),Xiao(P),Zhang(D),... PLoS One None

...JAK2, KDR, PAK4, PTK2 and PDGFRA being the core. Baicalein exhibits a conserved binding mode of "hinge hydrogen bond-aro...

Circulating CD117+/CD34+/CD45dim Myeloblasts as Biomarkers of Disease Activit...

Abdelmaksoud(MT),Hevessy(Z),Bedekovics(J),... EJHaem 2026-06-00

...JAK2 VAF and LDH levels among several other markers. Patients with overt MF had higher CMB-FC# and CMB-FC% compared to t...

LEP Knockdown Improves Functional Recovery After Spinal Cord Injury and Poten...

Chen(C),Tian(X),Zhang(W),Wang(X),Zhao(L),M... Neuromolecular Med 2026-05-17

...JAK2 and STAT3, promoted the shift of microglia from the M1 to the M2 phenotype, reduced iNOS, TNF-α, and IL-6, and incr...

Prognostic Score for Myelodysplastic Syndromes Based on Molecular Evolution.

Civettini(I),Malighetti(F),Villa(M),Crippa... NEJM Evid 2026-06-00

...JAK2]) were integrated into IPSS-M to generate IPSS-M-Evo. The model with "-Evo" improved discrimination for both leukem...

MLH1 silencing reprograms PI3K/AKT and JAK/STAT signaling to enhance 5-Fluoro...

Topal Kızıloğlu(H),Kara(A) DNA Repair (Amst) 2026-07-00

...JAK2, MLH1, MDR1, p53, and proteins; β-Actin was used as an internal control. CVDK-8 analysis showed that application of...

Agro-Industrial Plant Biomass as a Sustainable Source of Anticancer Polypheno...

Yazdanpanah(S),Sepe(F),Romano(S),Valentino... Curr Issues Mol Biol 2026-04-29

...JAK2/STAT6 pathways, thereby promoting apoptosis (in vitro and in vivo). In addition to their pharmacological potential,...

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