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Genome-wide assessment of the association of rare and common copy number vari...

Edsgärd(Daniel),Dalgaard(Marlene D),Weinho... Front Endocrinol (Lausanne) 2013-02-04

...PTPN1 (P = 3.8 × 10(-2), 0.9% of cases and 0% of controls). However, the CNV could not be verified by qPCR in the affect...

SRC signaling is crucial in the growth of synovial sarcoma cells.

Michels(Sebastian),Trautmann(Marcel),Sieve... Cancer Res 2013-06-12

...PTPN1) was conducted in 30 synovial sarcomas. Functional aspects of SRC, including dependence of SRC activation on the S...

PTP1B is an androgen receptor-regulated phosphatase that promotes the progres...

Lessard(Laurent),Labbé(David P),Deblois(Ge... Cancer Res 2012-05-14

...PTPN1 transcriptional start site. We found that PTPN1 and AR genes were coamplified in metastatic tumors and that PTPN1 ...

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing...

Murillo-Cuesta(Silvia),Camarero(Guadalupe)... Mol Med 2012-09-04

...Ptpn1⁺/⁺, Irs2⁺/⁺Ptpn1⁻/⁻ and Irs2⁻/⁻Ptpn1⁻/⁻ mice at different postnatal ages. The results indicated that Irs2⁻/⁻Ptpn1⁺...

Genetic profile of second primary tumors and recurrences in head and neck squ...

Gutiérrez(Virginia Franco),Marcos(César Ál... Head Neck 2012-10-24

...PTPN1 were associated with recurrences.,Specific genetic profiles for each group have been found. Similarities between p...

Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysi...

Noman(Muhammad Zaeem),Buart(Stéphanie),Rom... Cancer Res 2012-11-28

...PTPN1, HOXA1, and TP53I11 were miR-210 target genes regulated in hypoxic cells. In support of their primary importance i...

Food intake reductions and increases in energetic responses by hindbrain lept...

De Jonghe(Bart C),Hayes(Matthew R),Zimmer(... Am J Physiol Endocrinol Met... 2012-11-02

...Ptpn1(loxP/loxP) POMC-Cre), a negative regulator of CNS leptin signaling, results in resistance to diet-induced obesity ...

The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Speci...

Tsou(Ryan C),Bence(Kendra K) J Obes 2012-08-23

...PTPN1 gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity ...

Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to br...

Shi(Hong),Bevier(Melanie),Johansson(Robert... Breast Cancer Res Treat 2012-03-22

...PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms ...

Association of the PTPN1 gene with type 2 diabetes and insulin resistance.

Bowden(Donald W) Discov Med 2012-10-02

...PTPN1, a catalytic protein that removes phosphate groups from phosphorylated tyrosine residues) with T2DM and insulin re...

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