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H2S induces apoptosis of tumors with high IDO1 expression via NR4A1-BCL-2 and...

He(ZNT),Meng(F),Qian(X),Liu(Y),Fang(X),Yan... Cell Mol Biol Lett 2026-05-13

...SOCS3 are examined both in vitro and in vivo. In this study, we confirm our hypothesis by showing that H2S significantly...

LOXL4 drives radiotherapy resistance and immunosuppression in glioma by targe...

Du(G),Ding(Z),Hou(J),Su(Q),Li(Q),Xia(X),Ya... Int Immunopharmacol 2026-08-01

...SOCS3). This relieves SOCS3-mediated inhibition of JAK2, leading to sustained STAT3 activation. Consequently, this axis ...

Targeted peptide-modified M2 exosomes drug delivery system for the targeted r...

Zou(JR),Yang(D),Zhang(CM),Zhang(L),Zhang(H... Br J Pharmacol 2026-08-00

...SOCS3 and promoting tissue barrier reconstruction. Gene interaction network identified Spib-Pou2f1-Aicda/Tnfrsf4 as the ...

Integrated immune, apoptotic and mitochondrial gene dysregulation in Long COV...

Ali(YH),Abbas(U),Khalid(MU),Ahmed(I),Hussa... Sci Rep 2026-05-15

...SOCS3, HIF-1α, OAS1, MAVS, IFN-α, IFN-γ), anti-apoptotic markers (MCL1, BCL-2, XIAP, LIVIN), cell cycle kinases (CDK4, C...

IL-10-STAT3-Dependent Transcriptional Regulation in Microglia: Alzheimer's Di...

Kim(ME),Lee(JS) Biomedicines 2026-04-05

...Socs3 and Ccl5. Following IL-10 receptor activation, STAT3 binds regulatory regions of inflammatory genes, including Il1...

Structure-Guided SOCS3 Peptidomimetics: Design and Functional Characterizatio...

Cugudda(A),La Manna(S),Bucciero(C),Castell... ACS Omega 2026-04-28

...SOCS3-derived peptidomimetics that incorporate a hitherto unexploited structural determinant of the SOCS3/JAK2/Gp130 int...

Transcriptomic responses and molecular mechanisms of glucagon-regulated gluco...

Zhang(T),Wang(H),Xiao(T),Yang(M),Zhang(W) Front Physiol None

...SOCS3 and TRIB3 were upregulated and may serve as key regulators linking glucagon and insulin signaling. Functional expe...

Sodium Houttuyfonate improves cognitive impairment in mice after chronic slee...

Li(R),Zhu(Y),Wei(H),Yu(M),Xu(Y) Int Immunopharmacol 2026-07-01

...SOCS3/STAT3 pathway, and si-SOCS3 treatment significantly diminished these anti-inflammatory effects of SH, confirming t...

Reduced expression of SOCS1-5 and STAT5a genes in Parkinson's disease patient...

Salmani(M),Rastegari-Pouyani(M),Afshar(S),... Mol Biol Rep 2026-04-25

...SOCS3, SOCS5, and STAT5a genes in patients showed a significant decrease compared to the control group (p < 0.001, = 0.0...

Multidimensional transcriptomic analysis and in vitro experiments dissect the...

Sun(M),Hu(D),Li(T),Chen(Z),Cong(B),Xi(Z),W... Chem Biol Interact 2026-07-01

...SOCS3, SREBF1, and JUN) as core targets of BDE-47-driven BC progression. Molecular docking suggested favorable predicted...

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