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Efficient Mining for Structurally Diverse Fusicoccane-Type Diterpenoids as Nove…

Bao(A),Gong(X),Lin(S),Gao(C),Wang(H),Wang(D)… J Med Chem 2026-02-12

...Syk and PLCγ2 phosphorylation and subsequent platelet activation. In contrast, compound 31 exerts its antiplatelet effec...

TREM2 regulates neuroinflammation by SYK-dependent inhibition of BTK activation…

Zhang(K),Chi(W),Guo(J),Huang(Y),Zhang(Z),Guo… Int Immunopharmacol 2026-03-15

...SYK phosphorylation to inhibit BTK activity, an effect antagonized by the SYK inhibitor R406. Subsequent studies indicat...

Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and …

Qu(L),Du(W),Ren(Z),Chen(M),Wu(X),Cao(X),Rao(… Pharmaceuticals (Basel) 2026-01-22

...Syk/MAPK pathway. Conclusions: These findings indicate that Vas may effectively alleviate allergic asthma by reducing in...

Effects of PFOA and emerging alternatives at environmental concentrations on mu…

Wu(K),Zhou(S),Tang(A),Tao(J),Chen(Y),Zhou(H)… Environ Res 2026-03-01

...SYK signaling were determined. BMD data showed that PFOA exhibited greater neurotoxic potential than GenX and PFBS follo...

The involvement of CLec-HTM/IgR-Syk-BCL10-mTOR/ERK signaling pathway in immune …

Sun(J),Wu(W),Zhang(T),Wang(Z),Guo(Z),Yao(H),… J Immunol 2026-01-21

...Syk-BCL10 signaling pathway was interfered by silencing the expression of the main components, the phosphorylation of mT...

TREM2 activation by first-in-class direct small molecule agonists: DEL screenin…

Nada(H),Yuan(S),El Gaamouch(F),Cho(S),Kuncew… Eur J Med Chem 2026-01-15

...Syk phosphorylation, luciferase assay and enhanced microglial phagocytosis. Pre-liminary optimization yielded 4i, which ...

Unraveling the signaling mechanisms behind Histoplasma capsulatum-induced neutr…

Thompson-Souza(GA),Incutto(MM),Vasconcelos(C… Life Sci 2026-01-15

...Syk, contributing to fungal killing. In this study, we further elucidated the intracellular signaling pathways involved....

Mechanistic insights into PPARγ's role in suppressing collagen-driven platelet …

Wang(SB),Oh(EB),Kim(S),Sohn(J),Kim(T),Chang(… Life Sci 2026-01-15

...Syk, the upstream regulatory mechanisms remain unclear. This study aimed to determine whether PPARγ ligands modulate Src...

Decoding the pharmacokinetics of intravenous lentinan: A multiscale journey fro…

Mu(X),Wang(J),Wan(S),Wang(J),Huang(L),Wu(N),… Carbohydr Polym 2026-02-15

...Syk/FAK signaling pathway mediated the uptake of LNT by KCs and influenced the subsequent metabolism by regulating lysos...

Efficient Discovery of Syk-Targeting Phenolic Acids from Orthosiphon aristatus …

Qin(G),Sha(W),Zhang(M),Li(B),Guo(P),Wang(C),… J Agric Food Chem 2026-01-14

...Syk and then inhibit the GPVI pathway, which is unique to collagen-induced aggregation. The work laid the foundation for...

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