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Novel control of cAMP-regulated transcription in vascular endothelial cells.

Milne(Gillian R),Palmer(Timothy M),Yarwood... Biochem Soc Trans 2012-05-18

...SOCS3 (suppressor of cytokine signalling 3) gene, which attenuates pro-inflammatory cytokine signalling in VECs. These n...

TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis.

Jiang(Youde),Zhang(Qiuhua),Soderland(Carl)... Cell Signal 2012-06-06

...SOCS3) siRNA. Cell lysates were processed for Western blotting and ELISA analyses to verify TNFα and SOCS3 knockdown, as...

Influence of pregnancy on the adipocytokine and peroxisome proliferator-activ...

Weix(Janine),Förger(Frauke),Häupl(Thomas),... Arthritis Rheum 2012-09-14

...SOCS3, FADS2, STAT1, and CD36 proved to be differentially regulated by pregnancy. In samples from RA patients, the diffe...

Interferon-γ-stimulated genes, but not USP18, are expressed in livers of pati...

Dill(Michael T),Makowska(Zuzanna),Duong(Fr... Gastroenterology 2012-11-06

...SOCS3 between liver samples from patients with AHC and those with CHC. However, USP18 (another negative regulator of IFN...

Mycobacterium avium subsp. paratuberculosis inhibits gamma interferon-induced...

Arsenault(Ryan J),Li(Yue),Bell(Kelli),Doig... Infect Immun 2012-10-24

...SOCS3 as well as decreased expression of IFN-γ receptor chains 1 and 2 is observed in M. avium subsp. paratuberculosis-i...

SOCS1 gene expression is increased in severe pulmonary tuberculosis.

Masood(K I),Rottenberg(M E),Carow(B),Rao(N... Scand J Immunol 2012-11-27

...SOCS3 gene expression was determined by RT-PCR. Statistical analysis was performed using the Mann-Whitney test. Levels o...

Role of SOCS2 in modulating heart damage and function in a murine model of ac...

Esper(Lisia),Roman-Campos(Danilo),Lara(Ali... Am J Pathol 2012-10-29

...SOCS3 in the spleen. Expression of IFN-γ, TNF-α, SOCS1, and SOCS3 was also reduced in the hearts of infected SOCS2 KO mi...

Kaposi's sarcoma-associated herpesvirus inhibits expression and function of e...

Butler(L M),Jeffery(H C),Wheat(R L),Long(H... J Virol 2012-08-15

...SOCS3 (suppressor of cytokine signaling 3). Thus, KSHV infection resulted in transcriptional upregulation of SOCS3, and ...

Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Fox...

Ueda(Aki),Zhou(Liang),Stein(Paul L) J Immunol 2012-08-14

...Socs3, suggesting that Fyn may function upstream of a variety of molecular pathways that contribute to Th17 polarization...

Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of...

Gao(Yiwei),Cimica(Velasco),Reich(Nancy C) J Biol Chem 2012-08-24

...SOCS3). In this report we describe the finding that SOCS3 can also inhibit the unconventional target, Brk. Investigation...

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