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New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produce...

Ohshiro(Taichi),Matsuda(Daisuke),Kazuhiro(... J Antibiot (Tokyo) 2012-07-27

...ACAT2-expressing CHO cells. Three new compounds, verticilides A2, A3 and B1, were isolated along with a known compound, ...

Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.

Rogers(Maximillian A),Liu(Jay),Kushnir(Mar... J Biol Chem 2012-07-23

...ACAT2) convert various sterols to steryl esters; their activities are activated by cholesterol. PREG is a sterol-like mo...

Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is suffic...

Zhang(Jun),Kelley(Kathryn L),Marshall(Step... J Lipid Res 2012-09-07

...ACAT2(L-/L-)) and intestine-specific (ACAT2(SI-/SI-)) ACAT2 knockout mice and studied dietary cholesterol-induced hepati...

Human ACAT1 gene expression and its involvement in the development of atheros...

Li(Bo-Liang),Chang(Ta-Yuan),Chen(Jia),Chan... Future Cardiol 2012-10-02

...Acat2, exist in mammals. In the monocyte-macrophages, ACAT1 is the major isoenzyme and is a drug target for atherosclero...

Cholesterol esterification by ACAT2 is essential for efficient intestinal cho...

Nguyen(Tam M),Sawyer(Janet K),Kelley(Kathr... J Lipid Res 2012-04-09

...ACAT2⁻/⁻ mice was 16% compared with 46-47% in ACAT2⁺/⁺ and ACAT2⁺/⁻ mice. Chylomicrons from ACAT2⁺/⁺ and ACAT2⁺/⁻ mice c...

Isoform-specific inhibitors of ACATs: recent advances and promising developme...

Ohshiro(Taichi),Tomoda(Hiroshi) Future Med Chem 2012-03-09

...ACAT2. This review covers these studies and describes the future prospects of ACAT2-specific inhibitors.

Long-term curcumin administration protects against atherosclerosis via hepati...

Shin(Su-Kyung),Ha(Tae-Youl),McGregor(Robin... Mol Nutr Food Res 2012-04-05

...ACAT2 expression. Hepatic PPARα and LXRα expression was upregulated by curcumin treatment. Hepatic complement factor D (...

Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrat...

De Preter(Vicky),Arijs(Ingrid),Windey(Kare... Inflamm Bowel Dis 2012-10-25

...ACAT2) in UC and controls.,Colonic mucosal biopsies were collected during endoscopy of 88 UC patients and 20 controls wi...

Two novel cis-elements involved in hepatocyte nuclear factor 4α regulation of...

Zhang(Zhuqin),Liu(Jinjing),Xi(Yang),Yang(R... Acta Biochim Biophys Sin (S... 2012-05-18

...ACAT2) is important for cholesterol ester synthesis and secretion. A previous study revealed that ACAT2 gene promoter ac...

Pravastatin modulates liver bile acid and cholesterol homeostasis in rats wit...

Kolouchova(Gabriela),Brcakova(Eva),Hirsova... J Gastroenterol Hepatol 2012-01-23

...Acat2, and induced the expression of Abca1 and Mdr2. These changes corresponded with the upregulation of nuclear recepto...

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