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PGAM2 Regulates Sepsis-Induced Diaphragmatic Atrophy via the JAK2/STAT3 Pathway.

Chu(Y),Yuan(X),Gao(X),Luo(J) Biomedicines 2026-05-09

...JAK2/STAT3 pathway activation were assessed. Results: CLP induced significant diaphragmatic atrophy, as reflected by an ...

Hepatocarcinogenesis in Metabolic Dysfunction-Associated Steatotic Liver Dise...

Solleiro-Villavicencio(H),Méndez-García(LA... Biomedicines 2026-05-12

...Jak2, Tyk2, Socs3) showed minimal changes across stages, receptor subunits (Il10ra, Il10rb) and IL-10-responsive effecto...

Machine Learning-Based Identification of Immune Inflammation-Related Genes as...

Yang(R),Zhang(F),Huang(J) Biomedicines 2026-05-12

...JAK2, SLC39A7, and WASF3 as hub genes serving as common potential biomarkers for both diseases. Among them, BIN2, SLC39A...

Dual Empagliflozin and Sacubitril/Valsartan Therapy Improves Ex Vivo Cardiac ...

Murić(M),Srejović(I),Ravić(M),Joksimović J... Biomedicines 2026-05-14

...JAK2/STAT3 signaling. Methods: HF was induced in rats by 7-day isoproterenol administration and confirmed four weeks lat...

Paeoniflorin Ameliorates Cecal Ligation and Puncture-Induced Acute Lung Injur...

Shady(NH),Mohyeldin(RH),Reda Abdel Maqsoud... Pharmaceuticals (Basel) 2026-04-24

...JAK2/STAT3 signaling pathway. Network pharmacology analysis was used to identify potential molecular targets, and molecu...

Structure-Based Identification of JAK1-Selective Candidates Using Ensemble Do...

Stoian(N),Avram(S),Halip(L) Pharmaceuticals (Basel) 2026-04-30

...JAK2 catalytic-domain structures was clustered to capture binding-site diversity, and representative conformers were eva...

AARS1-mediated lactylation of STAT1 drives immune evasion.

Du(Y),He(M),Xu(Y),Tian(T),Zhou(Y),Zhang(Y)... Cell Rep 2026-03-24

...JAK2 and phosphorylation, thereby disrupting tumor responsiveness to IFN-γ, which leads to a reduction in the expression...

Beauvericin Induces Mitochondrial Apoptosis and Attenuates EMT-Associated Phe...

Kwon(M),Jung(HJ) J Microbiol Biotechnol 2026-03-13

...JAK2, STAT1, and STAT3. Collectively, these findings indicate that beauvericin modulates multiple malignant phenotypes o...

Identification of PANoptosis-Related Biomarkers in Hypertrophic Cardiomyopath...

Zhong(J),Zhao(Q),Wu(R),Zhang(S),Liu(G),Zha... J Inflamm Res None

...JAK2, MYC, S100A8) showed high diagnostic performance (AUC > 0.95). Two molecular subtypes displayed distinct immune and...

Molecular characterization of pediatric mastocytosis revealed different somat...

Kasmi(D),Giona(F),Ribersani(M),Sforzini(G)... Front Cell Dev Biol None

...JAK2 L393V; c-KIT D816Y; LNK E208Q; TET2 Y867H) and 5 not previously described (ETV6 A215P; c-KIT Y553C; NFE2 I291T; SH2...

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