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Discovery of actionable drug targets to enhance T-cell infiltration and immune …

Genugten(JHLTV),Faulkner(D),Hahne(JC),Poile(… Lung Cancer 2025-11-00

...SOX4, KDM5B, CMTM4) and five novel FDA-approved drug targets (SMO, GANAB, ERBB2, GABRA1, ODC1). Seven additional targets...

Molecular mechanism of modified Yigong San formula against colorectal cancer vi…

Wang(J),Zhang(XW),Tang(BW),Li(Z),Song(N) World J Gastrointest Oncol 2025-10-15

...SOX4) axis. In the clinical study, CRC tissues and corresponding adjacent normal samples that fulfilled inclusion criter...

HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Ce…

Roy(S),Miyauchi(S),Jones(RN),Kim(SS),Venuti(… Cancer Res 2025-10-15

...SOX4, in HPV E5 cells compared with empty vector cells. Knockdown of SOX9 restored sensitivity to chemo- and/or radiothe...

Scalable transcription factor mapping uncovers the regulatory dynamics of natur…

Mullins(RDZ),Zaretsky(J),Stoller(E),Moore(M)… bioRxiv 2025-10-10

...SOX4, and RBPJ. To derive biological insights from these data, we developed an analytical framework to integrate TF bind...

SOX4 enhances tumor progression and cisplatin resistance in orthotopic mouse xe…

Jang(HB),Kim(SA),Jung(EK),Lee(KH),Lee(JK),Jo… BMC Cancer 2025-10-14

...SOX4 modulation on cell proliferation, invasion, migration, and apoptosis was assessed. The results showed that SOX4 kno...

EIF4A3-induced circFAT1 promotes high glucose-induced podocyte damage via miR-3…

Huang(Y),Liu(Y),Yang(M),Zhao(L),Chen(M) RNA Biol 2025-12-00

...SOX4 expression, which promoted epithelial-mesenchymal transition and migration in podocytes. Moreover, we identified EI...

Single-cell multi-omics analysis reveals cancer regulatory elements of transcri…

Tang(X),Zhang(Q),Shen(Z),Xiao(J),Li(M),Meng(… Cell Death Dis 2025-10-21

...SOX4, TCF7, and TEAD4, which are pivotal in driving malignant transcriptional programs and represent potential therapeut...

Androgens Drive SOX9 Upregulation in Injured Proximal Tubular Cells.

Allison(CV),Patel(PS),Xuanyuan(Q),Stayton(A)… bioRxiv 2025-10-24

...Sox4, Sox11, Vgf, Zfp24, and the androgen receptor (Ar), along with gonadectomy and hormone replacement studies, combine...

Single-cell analysis of human thymus and peripheral blood unveils the dynamics …

Deng(Y),Peng(Z),Ming(K),Qiao(X),Ye(B),Liu(Y)… Nat Aging 2025-12-00

...SOX4 expression and inflammatory profiles but depleted of thymic epithelial cells and expression of tissue-restricted an...

Microdeletions on 6p22.3 are associated with mesomelic dysplasia Savarirayan ty…

Flöttmann(Ricarda),Wagner(Johannes),Kobus(Ka… J Med Genet 2016-03-15

...SOX4. All patients showed mesomelia of the lower limbs with hypoplastic tibiae and fibulae. We identified a fourth patie...

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