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FcεRIγ reinforces double-negative T cell-mediated antibody-dependent cellular c…

Shao(S),Han(X),Zhang(T),Yang(L),Li(M),Zhang(… J Mol Cell Biol 2026-07-03

...Syk) of FcεRIγ reduced cytotoxicity of DNT cells and phosphorylation levels of molecules such as AKT and NF-κB. In a sub...

Tunable enantioselective electrocatalytic functionalization of unactivated alke…

Xie(T),Liu(M),Zhang(J),Peng(L),Guo(C) Nat Commun 2026-01-02

...SYK inhibitor, signifying substantial progress in synthetic methods.

Esculetin mitigates mast cell-mediated allergic inflammation and anaphylaxis by…

Kim(D),Yoon(J),Jeong(NH),Choi(YA),Jin(M),Lee… Inflammopharmacology 2026-02-00

...Syk, ultimately reducing intracellular calcium influx. CONCLUSION: These findings suggest that esculetin may serve as a ...

ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody di…

Ishizu(H),Hasegawa(T),Shimizu(T),Yamamoto(T)… Bone 2026-04-00

...Syk signaling pathway in rebound-associated bone resorption using a murine model treated with and withdrawn from a RANKL...

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflamm…

Chen(H),Xu(S),Chen(B),Xiong(X),Hu(J),Wu(Y),W… J Diabetes Investig 2026-03-00

...Syk/CARD9/IRF5/NF-κB pathway, reduced macrophage and neutrophil infiltration, and suppressed inflammatory cytokine expre...

Identification and computational assessment of novel targeting sites of dexamet…

Dwivedi(SD),Rathor(LS),Singh(D),Singh(MR) In Silico Pharmacol None

...Syk), Interferon (IFN)-γ, Nicotinamide phosphoribosyl transferase (NAMPT) or Visfatin, NF-κB receptors which are respons...

Genome-Wide Insights into Intermittent Milking Behavior of Pandharpuri Buffalo.

Patil(A),Gaur(P),Pal(P),Alex(R),Chhotaray(S)… Curr Issues Mol Biol 2026-01-19

...SYK, INSR, PTPN11, VAV3, MAPK3, and PRKG1. These signatures provide insights into genomic regions and biological pathway...

PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models…

Cen(Y),R Alves(S),Song(D),Felice(C),Preall(J… Proc Natl Acad Sci U S A 2026-02-10

...SYK), a key regulator of microglial phagocytosis, as a direct substrate of PTP1B. Inhibition of SYK showed that PTP1B mo...

Efficacy and mechanism of action of sovleplenib for aplastic anemia.

Sheng(T),Sun(W),Xin(S),Zhou(C),Liu(H) Hematology 2026-12-00

...SYK inhibitor, in aplastic anemia (AA), focusing on its effects on immune modulation and the cGAS-STING-NF-κB inflammato...

Identification of Mannose-Capped-Arabinomannan 101-mer as a Potential Influenza…

Zhang(YF),Xu(R),Luo(J),Ma(Y),Xiao(G),Liu(Y) Adv Sci (Weinh) 2026-04-00

...Syk/NF-κB signaling. This study provided a new oligosaccharide candidate that can satisfy the required "efficacy-safety"...

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