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The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyr…

Emami-Nemini(Alexander),Gohla(Antje),Urlaub(… Mol Pharmacol 2012-10-09

...vav2, a guanine nucleotide exchange factor (GEF) for Rho GTPases, as a PTHR-interacting protein. The core domains of vav...

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signali…

Kajla(Seheli),Mondol(Abdus S),Nagasawa(Atsus… FASEB J 2012-06-29

...Vav2 by Src-mediated tyrosine phosphorylation. Nox1-generated ROS oxidize and inactivate NRX, thereby releasing the NRX-...

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, prol…

Chang(Kyung Hee),Sanchez-Aguilera(Abel),Shen… Blood 2012-10-09

...Vav2-deficient B-cell progenitors increases the transformation ability of p190-BCR-ABL. Vav3 deficiency induces apoptosi...

IbeA and OmpA of Escherichia coli K1 exploit Rac1 activation for invasion of hu…

Maruvada(Ravi),Kim(Kwang Sik) Infect Immun 2012-07-17

...Vav2, not β-Pix, was involved in E. coli K1-mediated Rac1 activation. Since activated STAT3 is known to bind GTP-Rac1, t...

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.

Montalvo-Ortiz(Brenda L),Castillo-Pichardo(L… J Biol Chem 2012-06-19

...Vav2, EHop-016 inhibits the association of Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activat...

The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of…

Krause-Gruszczynska(Malgorzata),Boehm(Manja)… Cell Commun Signal 2012-10-02

...Vav2 is required for Cdc42 activation and maximal bacterial invasion. Overexpression of certain mutant constructs indica...

Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in pla…

Fukumoto(Yuri),Kurita(Souichi),Takai(Yoshimi… J Biol Chem 2012-03-27

...Vav2, a GDP/GTP exchange factor for Rac, in a Src phosphorylation-dependent manner, suggesting that ADIP mediates the ac...

Detection of Rho GEF and GAP activity through a sensitive split luciferase assa…

Anderson(Erik L),Hamann(Michael J) Biochem J 2012-03-15

...Vav2, Trio and Asef) and GAPs [p190, Cdc42 GAP and PTPL1-associated RhoGAP]. The assay detected activities associated wi...

Proteomic analysis of microvesicles derived from human mesenchymal stem cells.

Kim(Han-Soo),Choi(Do-Young),Yun(So Jeong),Ch… J Proteome Res 2012-07-10

...VAV2); (3) cell adhesion (FN1, EZR, IQGAP1, CD47, integrins, and LGALS1/LGALS3); and (4) MSC-associated antigens (CD9, C...

Gene expression profile of mesenchymal stromal cells after co-culturing with in…

Cho(Kyung-Ah),Ju(Sun-Young),Ryu(Kyung-Ha),Wo… Mol Med Rep 2012-10-02

...Vav2 was upregulated. Our research provides information regarding the differential molecular mechanisms that regulate th...

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