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KRAS driven expression signature has prognostic power superior to mutation st...

Nagy(Ádám),Pongor(Lőrinc Sándor),Szabó(And... Int J Cancer 0000-00-00

...KRAS expression were not correlated to prognosis. The transcriptomic fingerprint of KRAS include FOXRED2, KRAS, TOP1, PE...

Prognostic Impact of Primary Tumor Location on Clinical Outcomes of Metastati...

Sunakawa(Yu),Ichikawa(Wataru),Tsuji(Akihit... Clin Colorectal Cancer 0000-00-00

...KRAS exon 2 wild-type tumors who were enrolled onto 2 clinical trials: JACCRO CC-05 of cetuximab plus FOLFOX (n = 57, UM...

GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumori...

Kayama(Kota),Watanabe(Shinya),Takafuji(Tak... EMBO Rep 0000-00-00

...KRAS confers anchorage-independent growth and tumorigenic capacity on normal human fibroblasts. Consistent with this, GR...

Anti-EGFR monoclonal antibodies enhance sensitivity to DNA-damaging agents in...

El Guerrab(Abderrahim),Bamdad(Mahchid),Big... Mol Carcinog 0000-00-00

...KRAS) and two tumor suppressor genes (PTEN and BRCA1). Both mAbs failed to improve the cytotoxic effect of chemotherapie...

RNF43 Mutation Frequently Occurs With GNAS Mutation and Mucin Hypersecretion ...

Tsai(Jia-Huei),Liau(Jau-Yu),Yuan(Chang-Tsu... Histopathology 0000-00-00

...KRAS (P = .074) mutation. The presence of macroscopic mucin hypersecretion was closely related to RNF43 (P = .024) and G...

Genetics of Pancreatic Cancer and Its Implications on Therapy.

Tatarian(Talar),Winter(Jordan M) Surg Clin North Am 0000-00-00

...KRAS, CDKN2A, TP53, SMAD4), new genes and pathways have been implicated. However, these efforts have not identified any ...

Molecular Pathogenesis of Pancreatic Cancer.

Grant(T J),Hua(K),Singh(A) Prog Mol Biol Transl Sci 0000-00-00

...KRAS oncogene, which is a potent driver of tumor initiation and maintenance. Inactivating mutations in tumor suppressor ...

A Comparison of Cell-Free DNA Isolation Kits: Isolation and Quantification of...

Sorber(Laure),Zwaenepoel(Karen),Deschoolme... J Mol Diagn 0000-00-00

...KRAS mutated cell-free tumor DNA (ctDNA). Digital droplet PCR was used to quantify the total cfDNA concentration as well...

Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and m...

Gore(Jesse),Imasuen-Williams(Imade E),Cont... Cancer Lett 0000-00-00

...Kras; deleted RB) and KIC (mutated Kras; deleted INK4a) genetic models. Moreover, pancreatic cancer cells (PCCs) derived...

Specific KRAS amino acid substitutions and EGFR mutations predict site-specif...

Renaud(Stéphane),Seitlinger(Joseph),Falcoz... Br J Cancer 0000-00-00

We aimed to evaluate whether EGFR mutations (mEGFR) and KRAS amino acid substitutions can predict first site of recurren...

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