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Cytotoxicity and potential cell death mechanisms of three new benzamidine der...

Loh(TKFY),Lee(MF),Agouni(A),Fuloria(NK),Fu... Cytotechnology 2026-06-00

...AIM2), molecular simulation results further confirmed the stability, structural compactness and residual flexibility. In...

Modulation of Inflammasome Activity by miR-197-3p in Familial Mediterranean F...

Akkaya-Ulum(YZ),Sen(B),Akbaba(TH),Balci-Pe... Arch Rheumatol 2026-04-03

...AIM2, and NOD-like receptor protein 3 pathways. Interleukin-1β (IL-1β) secretion and pro-IL-1β expression were subsequen...

Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumo...

Chen(Y),Wu(H),Wu(X),Che(L),Fu(X),Qi(R),Jia... Int J Mol Med 2026-06-00

...AIM2 signaling pathway in THP‑1 cells but not in HBEpiCs. However, overexpression of AIM2 in THP‑1 cells markedly revers...

Antioxidant defenses of Francisella tularensis perturb Aim2 Inflammasome Acti...

Ma(Z),Miller(J),Fantone(K),Bakshi(CS),Mali... bioRxiv 2026-04-11

...Aim2) detects double-stranded DNA in the cytosol of infected cells and subsequently assembles a multiprotein complex kno...

The NF-κB-driven inflammatory cascade in ischemic stroke: Linking DAMPs, infl...

Liu(Y),Zhang(Y) Gene 2026-07-15

...AIM2-related pathways. Beyond cell-intrinsic effects, NF-κB also mediates glial crosstalk and contributes to endothelial...

Extrachromosomal circular DNA (eccDNA) in immune regulation and autoimmunity:...

Le(HBC),Somsri(K),Bhunyakarnjanarat(T),Suk... Asian Pac J Allergy Immunol 2026-03-00

...AIM2 to drive type I interferon and pro-inflammatory cytokine responses. In the adaptive immune system, eccDNA is not me...

Gambogic acid inhibits tumor growth and induces HMGB1-mediated pyroptosis in ...

Yang(Y),Liu(H),Zou(M),Jiang(M),Chen(H),Wan... Phytomedicine 2026-06-00

...AIM2 inflammasome pathway. GA did not aggravate HMGB1 knockdown induced cell cycle arrest, DNA damage, and pyroptosis. G...

Integration of multi-omics and machine learning to identify core genes in PAN...

Chen(Z),Deng(X),Yu(Y),Zhang(T),Liu(C) Naunyn Schmiedebergs Arch P... 2026-06-00

...AIM2/RIPK3/CASP1 death complex and inhibiting the TLR4/NLRP3 survival signaling axis. This study systematically revealed...

Immunomodulatory effects of mesenchymal stem cell-derived extracellular vesic...

Mellado(S),Moreno-Manzano(V),Guerri(C),Pas... Mol Biol Rep 2026-04-07

...Aim2) and downstream effector genes (Casp-1, Casp-11/4, Il1b, and Il18) across the prefrontal cortex, hippocampus, and s...

NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinfla...

Haseeb(M),Choi(H),Jeong(U),Kim(MS),Choi(S) Int J Biol Macromol 2026-05-00

...AIM2 signaling, as shown by immunoblotting and biophysical analyses. Mechanistic studies demonstrated direct NLRP3 bindi...

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