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Pertubation of B and T cell development and predisposition to lymphomagenesis i…

Alkema(MJ),Jacobs(H),van Lohuizen(M),Berns(A) Oncogene 1997-08-18

...Bmi1 gene has implicated Bmi1 as a collaborator of c-Myc in lymphomagenesis. To determine the effect of Bmi1 overexpress...

BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric c…

Zhang(XW),Sheng(YP),Li(Q),Qin(W),Lu(YW),Chen… Mol Cancer 2010-02-21

...BMI1. BMI1 but not Mel-18 was found to be an independent prognostic factor. Downregulation of BMI1 by Mel-18 overexpress...

Bmi1 knockdown inhibits hepatocarcinogenesis.

Ruan(ZP),Xu(R),Lv(Y),Tian(T),Wang(WJ),Guo(H)… Int J Oncol 2013-01-00

...Bmi1 was used to assess the effects of Bmi1 in hepatocarcinogenesis. Bmi1 downregulation reduced cell growth...

Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen recep…

Ojo(D),Lin(X),Wu(Y),Cockburn(J),Bane(A),Tang… Cancer Lett 2018-00-10

...BMI1 knockdown sensitized the process. In MCF7-derived tamoxifen resistant cells, BMI1 expression was upregulated and BM...

BMI1 is directly regulated by androgen receptor to promote castration-resistanc…

Zhu(S),Zhao(D),Li(C),Li(Q),Jiang(W),Liu(Q),W… Oncogene 2020-00-00

...BMI1. Next, we showed that dihydrotestosterone (DHT) upregulated both mRNA and protein levels of BMI1 and that BMI1 was ...

MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BM…

Huang(R),Cheung(NK),Vider(J),Cheung(IY),Gera… FASEB J 2011-12-00

...BMI1 promoter and up-regulated BMI1 gene expression. shRNA-mediated knockdown of MYCN or MYC decreased BMI1 gene express...

Bmi1 loss produces an increase in astroglial cells and a decrease in neural ste…

Zencak(D),Lingbeek(M),Kostic(C),Tekaya(M),Ta… J Neurosci 2005-06-15

...Bmi1 promotes cell cycle progression, controls cell senescence, and is implicated in brain development. Loss of Bmi1 lea...

Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer.

Maynard(MA),Ferretti(R),Hilgendorf(KI),Perre… Oncogene 2014-07-10

...Bmi1 is required for both progression and maintenance of small intestinal adenomas. Importantly, Bmi1 deficiency did not...

BMI1 promotes the progression of laryngeal squamous cell carcinoma.

Chen(H),Zhou(L),Wan(G),Dou(T),Tian(J) Oral Oncol 2011-06-00

...BMI1 in laryngeal squamous cell carcinoma (SCC). Expression of BMI1 in primary tumors was analyzed by immunofluorescence...

βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.

Sahasrabuddhe(AA),Dimri(M),Bommi(PV),Dimri(G… Cell Cycle 2011-04-15

...BMI1. Furthermore, a mutant of BMI1 with an altered βTrCP recognition motif is much more stable than wild-type BMI1. We ...

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