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The chaperonin TRiC component Cct3 is required for axonal transport, myelinat...

Zhang(X),Zajt(KK),Palaz(T),Wang(L),Groß(M)... Cell Death Dis 2026-02-12

...Cct3 in neurodevelopment, particularly in myelin formation and the neuromuscular system using zebrafish as a model syste...

CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senesce...

Cao(Y),Xu(C),Liu(Y),Shi(B),Li(X),Li(J),Zha... iScience 2026-03-20

...CCT3. Functionally, CCT3 depletion induced robust G1 phase arrest, promoted cellular senescence, and markedly diminished...

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor ...

Chen(SY),Yang(LH),Liang(ZQ),Li(JD),Li(SD),... Cancer Med 2026-08-00

...CCT3, C19orf53, UACA, PPM1M, and LIN37 as key genes mediating TKI resistance in HCC. These six genes were found to be hi...

Ttyh3 ameliorates myocardial ischemia-reperfusion injury by activating Akt1 s...

Xu(Y),Lang(R),Xian(J),Li(Y),Xu(H),Zhang(J)... Biochem Biophys Res Commun 2026-09-17

...Cct3, a novel regulator linked to apoptosis regulation. Silencing Cct3 reversed Ttyh3-induced Akt1 phosphorylation and c...

Interplay between exosomes and the PD-1/PD-L1 axis in hepatocellular carcinom...

Chen(M),Wang(W),Jie(D),Gu(L) Crit Rev Oncol Hematol 2026-06-00

...CCT3, and specific long non-coding RNA (lncRNA) signatures further demonstrate strong predictive value for ICI response....

CCT3 Enhances Lung Adenocarcinoma Progression by Promoting p53 Ubiquitination...

Liu(H),Mao(F),Zhang(Y),Chen(J),Fan(J),Huan... Medicina (Kaunas) 2026-08-01

...CCT3 overexpression, whereas p53 inhibition weakened the p53 increase induced by CCT3 knockdown. In vivo, CCT3 depletion...

Integration of transcriptome profiling to identify key genes involved in the ...

Fang(H),Zhu(G),Chen(J),Zou(T) Front Psychiatry None

...CCT3, EIF3I, and RPS5, were further identified through enrichment analysis and protein-protein interaction (PPI) network...

Multimodal AI-Driven Identification of Dehydrocostus Lactone as a Potent Rena...

Lin(W),Xu(W),Liu(K),Wang(P),Zhu(Z),Lu(W),Z... Adv Sci (Weinh) 2026-04-00

...CCT3. These findings highlight the potential of DCL as a promising therapeutic candidate for renal fibrosis, providing n...

Machine learning-driven multi-omics analysis identifies a prognostic gene sig...

Li(X),Yin(D),Geng(J),Xu(Y),Xu(Z),Yang(X),L... Biol Proced Online 2025-08-09

...CCT3, a key gene in the model, was enriched in tumor regions, and its silencing was found to inhibit the proliferation a...

A Retrospective Study in Colorectal Adenocarcinoma Uncovers the Potential of ...

Kokoropoulos(P),Christodoulou(S),Tsiakanik... Biomedicines 2025-10-06

...CCT3) gene, namely circ-CCT3, is a significant oncogenic driver. In gastrointestinal malignancies, circ-CCT3 promotes tu...

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