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Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells.

Park(SG),Lee(D),Seo(HR),Lee(SA),Kwon(J) Sci Rep 2020-00-01

...CECR2). We show that NVS-CECR2-1 inhibits chromatin binding of CECR2 BRD and displaces CECR2 from chromatin within cells...

Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectode…

Fairbridge(NA),Dawe(CE),Niri(FH),Kooistra(MK… Birth Defects Res A Clin Mol … 2010-08-00

...Cecr2(Gt45Bic) is a hypomorphic mutation. We therefore generated a novel Cecr2 null allele (Cecr2 (tm1.1Hemc)). Resultin...

CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the test…

Thompson(PJ),Norton(KA),Niri(FH),Dawe(CE),Mc… J Mol Biol 2012-02-03

...CECR2/ISWI complexes in the testis showed that SNF2H interacted with CECR2, and this interaction was also observed in em...

Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d]…

Lu(H),Lu(T),Zu(S),Duan(Z),Guang(Y),Li(Q),Ma(… Bioorg Chem 2022-00-00

...CECR2) bromodomain is a module of CECR2-containing remodeling factor (CERF), which is a chromatin remodeling complex cor...

CECR2, a protein involved in neurulation, forms a novel chromatin remodeling co…

Banting(GS),Barak(O),Ames(TM),Burnham(AC),Ka… Hum Mol Genet 2005-02-15

...CECR2, which is involved in neurulation and chromatin remodeling. CECR2 shows complex alternative splicing, but all vari...

Overexpression of cat eye syndrome chromosome region, candidate 2 in esophageal…

Zhu(H),Kanda(M),Shimizu(D),Sato(Y),Bayasgala… Clin Transl Oncol 2026-02-00

...CECR2 enhanced proliferation of low-CECR2-expressed cell line. Mechanistically, CECR2 upregulates NF-κB signaling, downr...

Double whammy: the genetic variants in CECR2 and high Hcy on the development of…

Bai(B),Jiang(Q),Liu(L),Liu(C),Zhang(Q) Front Genet 2023-00-00

...CECR2. This investigation aims to explore the genetic influence of the chromatin remodeling gene, CECR2, in humans and d...

The CECR2 bromodomain displays distinct binding modes to select for acetylated …

Phillips(M),Cook(ED),Marunde(MR),Tonelli(M),… bioRxiv 2024-12-11

...CECR2 bromodomain (CECR2-BRD) plays a pivotal role in directing the activity of CECR2 through its capacity to recognize ...

Molecular cloning of chicken Cecr2 and its expression during chicken embryo dev…

Chen(J),Morosan-Puopolo(G),Dai(F),Wang(J),Br… Int J Dev Biol 2010-00-00

Cecr2 is a transcription factor involved in neurulation and chromatin remodeling. In the present study, the full length ...

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear developmen…

Dawe(CE),Kooistra(MK),Fairbridge(NA),Pisio(A… Dev Dyn 2011-02-00

The loss of Cecr2, which encodes a chromatin remodeling protein, has been associated with the neural tube defect (NTD) e...

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