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Integrated WGCNA of lncRNA-mRNA Networks Identifies Novel Hub Genes and Poten...

Wu(T),Jin(J),Yang(Y),Sui(J),Zhou(Y),Yuan(H... Int J Mol Sci 2026-01-27

...CSF1R, HCK, and CASP1. Based on this hub gene signature, AB-1010, GW768505A, and Dasatinib were identified as potential ...

Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia.

Shi(X),Arreola(AX),Zhou(Z),Yang(J),Liu(M),... Cancer Cell 2026-05-11

...CSF1R antibody, or Rearranged during Transfection (RET) inhibitor markedly reduces both cachexia and anorexia. These fin...

Temporal modulation of microglial repopulation attenuates retinal degeneratio...

Zhang(W),Bian(B),Ren(C),Chen(M),Fang(Y),Zh... Neurobiol Dis 2026-04-00

...CSF1R inhibitor PLX5622, we achieved efficient microglial depletion during the peak of degeneration (P21), followed by s...

Systemic CSF1R Targeting Depletes Pathogenic MPS Bubs and Ameliorates Psorias...

Lin(ZJ),Li(Y),Yu(Y),Fang(MJ),Xiong(Y),Xu(R... Theranostics None

...CSF1R) remain undefined. We aimed to identify pathogenic CSF1Rhigh MPS subsets, characterize their ligand-receptor circu...

Diversity and function of tumor-associated macrophages in brain metastases: m...

Ma(Y),Wang(H),Dou(X),Li(Q) Front Immunol None

...CSF1R inhibitors), combining TAM-targeted therapy with immune checkpoint inhibitors, and developing novel approaches suc...

More than microglial depletion: PLX5622 activates the hepatic constitutive an...

Cao(K),Cheng(W),Qiu(L),Wang(Z),Zhao(Y),Yua... Neuron 2026-04-15

The colony-stimulating factor 1 receptor (CSF1R) inhibitor PLX5622 has been widely used to deplete microglia for functio...

Colony-stimulating factor 1 receptor inhibition is neuroprotective to photore...

Pastor-Puente(S),Jung(R),Gonzalez-Buendia(... Cell Death Dis 2026-02-26

...CSF1R). Targeting the CSF1R has been proposed as a potential strategy to modulate neuroinflammation. Using PLX5622, a se...

CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting lipos...

Song(WQ),Wu(YQ),Zhu(QF),Xia(XP),Wang(R),Ya... Acta Pharmacol Sin 2026-06-00

...CSF1R) inhibitors. We previously developed a CSF1R inhibitor, C19, for TAM-targeting immunotherapy, which can reprogram ...

Embryonic and postnatal macrophages are necessary for proper tooth developmen...

Gonzalez Lopez(M),Katsura(KA),Neves(VCM),S... Nat Commun 2026-07-17

...Csf1R knockout mouse models. This results in abnormal dentin and enamel deposition, eruption defects, early tooth mispat...

Integrated Bioinformatics and Network Analysis Identifies Key Molecular Targe...

Zubair(A),Ali(M),Alkhedaide(AQ) J Mol Neurosci 2026-07-20

...CSF1R, CCR5, and CD4. This study suggests that the immune response plays an important role in the ZIKV infection. The st...

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