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DEAH-Box RNA Helicases in the Spliceosome: Advances in Structure and Function...

Chen(Z) FASEB J 2026-02-28

...DHX8/Prp22, DHX15/Prp43, and DHX35-bound to their RNA targets within distinct spliceosomal states. These structures reve...

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-...

Tall(JR),Te Poele(R),Vasile(A),Ramagiri(P)... NAR Cancer 2026-03-00

...DHX8). We investigated the role of DHX8 in regulating HSF1 within the broader context of DHX8 function in cancer cells. ...

DHX8 Plays a Critical Role in Larval Development in Lepidopteran Bombyx mori.

Ding(L),Xu(C),Zhang(Y),Wang(Y),Hou(Y),Shen... Insects 2026-02-25

...DHX8 (BmDHX8), we generated knockout mutants using CRISPR-Cas9 genome editing. Genome sequencing confirmed frameshift mu...

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box...

Read(BJ),Ewens(C),Gigante(F),Thomas(J),Fel... J Med Chem 2026-08-13

Human DHX8 is a spliceosomal DEAH-box RNA helicase involved in releasing mRNA from the spliceosome and crucial in ensuri...

Trio Whole Exome Sequencing in Chinese Childhood-Onset Lupus Reveals Novel Ca...

Ma(J),Qin(Y),Hong(SM),Ware(T),Hou(G),Tan(J... Arthritis Rheumatol 2025-11-00

...DHX8 and ACTR5, enhanced type I IFN signaling. This study highlights the abundance of lupus-relevant rare gene variants ...

DHX8 regulates degradation of RNA by RNautophagy.

Sakai(R),Takeda(E),Kabuta(C),Contu(VR),Fuj... Nucleic Acids Res 2025-08-11

...DHX8 as a binding partner. DHX8 interacts with SIDT2 and is partially localized to the cytoplasmic side of the lysosomal...

The Fish Collagen Supplementation and Proteomic Features in Healthy Women-A C...

Stelmach-Mardas(M),Matuszewska-Mach(E),Kus... Nutrients 2025-09-24

...DHX8, and FERM domain-containing protein 4A. Conclusions: Changes in serum proteins may reflect broader cytoskeletal rem...

Identification of cellular proteins required for replication of human immunod...

Dziuba(Natallia),Ferguson(Monique R),O'Bri... AIDS Res Hum Retroviruses 2013-02-19

...DHX8, DNAJA1, GTF2E1, GTF2E2, HAP1, KALRN, UBA3, UBE2E3, and VMP1. Candidate genes were independently tested in primary ...

Incomplete splicing, cell division defects, and hematopoietic blockage in dhx...

English(Milton A),Lei(Lin),Blake(Trevor),W... Dev Dyn 2012-09-20

...dhx8 in the mmy fish. dhx8 is the zebrafish ortholog of the yeast splicing factor prp22, which is a DEAH-box RNA helicas...

SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 m...

Chen(Yupeng),Zhang(Lirong),Jones(Katherine A) Genes Dev 2011-05-19

...DHX8 and Prp19 are also selectively required for p21(Cip1) expression under stress. Together, these studies define a new...

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