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A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical...

Arcanjo(GS),Silva(AP),Diniz(MV),Domingos(I... Br J Haematol 2026-06-00

...HBS1L-MYB rs9399137 polymorphisms with HbF levels and clinical complications in a cohort of 409 adult Brazilian SCA pati...

TNG961 is a selective oral HBS1L molecular glue degrader for the treatment of...

Nicholson(HE),Whittington(DA),Bruzzese(FJ)... Cancer Discov 2026-04-19

...HBS1L-CRBN-compound complex formation, and induced E3-ligase-dependent HBS1L ubiquitination and degradation. Guided by c...

Global genetic modifiers of fetal hemoglobin in sickle cell disease: Systemat...

Shende(N),Athalye(S),Kamath(S),Rani(P),Mad... iScience 2026-09-18

...HBS1L-MYB intergenic region (rs4895441, rs28384513), HBG2 (rs7482144), and HMOX1 (rs2071746). Meta-analysis confirmed di...

Genetic dissection of clinical heterogeneity in hemoglobin H patients by targ...

Ye(Y),Niu(C),Mao(A),Chen(L),Qin(L),Chen(W)... J Genet Genomics 2026-04-24

...HBS1L exert significant effects on β-thalassemia but not on HbH patients. This study presents the largest T-LRS study fo...

Fetal Hemoglobin Modulation in Sickle Cell Disease: βs Haplotypes, Key Polymo...

Márquez-Benitez(Y),Osorio-Garzón(VI),Berna... Genes (Basel) 2026-01-27

...HBS1L-MYB (HMIP), and the HBB cluster explain a significant proportion of HbF variability across populations. Furthermor...

Systematic Review of Non-Coding Genomic Variants in Globin and Non-Globin Clu...

Al-Subaie(AM),Borgio(JF) J Clin Med 2026-02-09

...HBS1L-MYB loci). Non-globin NCVs in the UGT1A1 promoter were also found to influence the severity measures in β-thal and...

Molecular genetics analysis of genes BCL11A, HBS1L-MYB, and HBG2 variants ass...

Lu(R),Bashir(K),Tayyaba Manzoor(H),Imran(A... Per Med 2026-09-08

Association of the BCL11A (rs4671393), HBG2 (rs7482144), and HBG2HBS1L-MYB (rs28384513, rs9399137, and rs4895441) varian...

Integrative analysis of the roles and prognostic value of RNA-binding protein...

Niu(T),Li(Q),Zhang(A) Discov Oncol 2026-06-19

...HBS1L, ELAC2, MRPL34, NOP2 and IGF2BP2, for their prognostic relevance. A prognostic risk score model for overall surviv...

BCL11A and HBS1L-MYB polymorphisms, in association with hydroxyurea and sex, ...

de Magalhães Filho(MF),Santana(ILR),da Sil... Mol Biol Rep 2026-06-23

...HBS1L-MYB intergenic region. In this study, we investigated the combined effects of HU therapy, βS-globin haplotypes, an...

Genomic basis of developmental defects of enamel and sex-specific effects.

Shrestha(P),Graff(M),Gu(Y),Wang(Y),Ahn(HS)... medRxiv 2026-07-10

...HBS1L and MYB , genes regulating hematopoiesis with plausible roles in amelogenesis. Joint test and sex-stratified analy...

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