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Chrysogenones A-E: Malonyl-Modified Ergosterone Derivatives from Deep-Sea-Der...

Li(Z),Chen(L),Wang(Y),Jiang(M),Fang(S),Cha... Mar Drugs 2026-03-23

...NRK-49F cell proliferation. Integrated network pharmacology analysis and molecular docking studies further suggested tha...

Targeting USP4 to inhibit TGF-β signaling: the antifibrotic potential of isov...

Fan(J),Liu(Y),Zhan(S),Ling(H),Yan(J),Xie(L... Phytomedicine 2026-06-00

...NRK-52E). Assays included biophysical target engagement (MST, CETSA, DARTS); biochemical analyses (ubiquitination, cyclo...

CaSR regulates SLC26A6 expression via the PKA-FOXO4 signaling axis to promote...

Gan(L),Li(W),Luo(P),Zhang(F),Zhong(H),Xie(... Front Cell Dev Biol None

...NRK-52E) were intervened with calcium oxalate monohydrate (COM) crystals and treated with agonists or inhibitors of CaSR...

LCZ696 (Sac/Val) protects against high-fat diet-induced kidney injury in mice...

Wang(W),Huang(Y),Guo(X),Cao(Z),Jiang(H),Zh... Cell Signal 2026-08-00

...NRK-52E cells were used to evaluate the renoprotective effects of LCZ696. Renal function, histopathology, and fibrosis w...

Multi-omics reveals that chenodeoxycholic acid promotes calcium oxalate kidne...

Liang(Y),Si(S),Gao(R),Lin(B),Wei(Y),Wu(Z),... J Nutr Biochem 2026-09-00

...NRK-52E cells treated with oxalate and CDCA, indicating that CDCA may promote kidney stone formation by inhibiting CAT. ...

Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polari...

Fan(J),Liu(Y),Zheng(C),Liu(J),Liu(W),Geng(... J Inflamm Res None

...NRK-52E) model. Finally, a DKD rat model was established to confirm the therapeutic efficacy in vivo and to mechanistica...

TRPV4-dependent PI3K-Akt activation mediates hyperosmotic stress-induced cell...

Miyano(T),Sakamoto(N),Sera(T) Exp Cell Res 2026-05-01

...NRK-52E cells, we conducted a targeted pharmacological screening of mechanosensitive receptor modulators, identifying tr...

Hybrids of 2-phenylchromone with phenylpropanoid from the agarwood of Aquilar...

Li(YF),Huang(XL),Zhang(Y),Xia(GG),Wang(YZ)... Fitoterapia 2026-04-00

...NRK-52e cells. Interestingly, the dextro-isomers [(+)-4 and (+)-5] showed more prominent activities than laevo-isomers [...

Nesfatin-1 attenuates renal interstitial fibrosis, oxidative stress, and infl...

Lahane(GP),Bhat(A),Dhar(A) Biochem Pharmacol 2026-07-00

...NRK-49F cells. UUO-induced renal fibrosis in mice and TGF-β1-stimulated NRK-49F fibroblasts were used to assess the anti...

Role of NOX4 and GSH in Cadmium-Induced Renal Redox Homeostatic Dysregulation...

Long(Z),Wei(L),Wang(C),Wang(N),Song(L),Liu... Biol Trace Elem Res 2026-07-00

...NRK-52E cells to further elucidate the regulatory role of NOX4 in Cd-mediated nephrotoxicity. Cd exposure caused signifi...

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