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Ultrarare Variants in DNA Damage Repair and Mitochondrial Genes in Pediatric Ac…

Vettiatil(D),Soorajkumar(A),Dubin(RA),Pedros… Dev Neurosci 2026-02-09

...PIDD1, ADNP, FANCD2, and RAD54L). The CUX1 variant is de novo, as are two cases that had mutations in genes that affect ...

Cytotoxicity in vitro assay in 3D vs. 2D L929 cell cultures - comparative analy…

Gruber-Bzura(B),Bubko(I),Mielczarek(L),Pogor… PLoS One None

...Pidd1 and Cyp3a44 genes, and - to check whether this potential response depends on the cell age. To achieve these goals ...

PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that…

Shah(RB),Li(Y),Person(A),Frigon(L),Ðukić(N),… Sci Adv 2026-05-00

...PIDD1 DD, which enables PARP4 docking. PIDD1 ADPr is dispensable for the recruitments of RAIDD and caspase-2 but essenti...

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart de…

Leone(M),Kinz(N),Eichin(F),Obwegs(D),Sladky(… Cell Death Differ 2026-06-00

...PIDD1 to mother centrioles. Opposite to prior observations in liver development, the PIDDosome limits CM polyploidizatio...

Genetic etiology of ventriculomegaly in 73 fetuses identified by High-Throughpu…

Chenyue(Z),Huiqin(X),Jingbo(G),Min(G),Hao(Y)… Sci Rep 2025-07-02

...PIDD1, RTTN, FGFR3, AIMP1, POGZ, MYH7, CNOT3, MACF1, and PURA gene, with 10 novel variants reported. Fetal VM is associa...

Ultrarare Variants in DNA Damage Repair and Mitochondrial Genes in Pediatric Ac…

Vettiatil(D),Soorajkumar(A),Dubin(RA),Pedros… medRxiv 2025-08-27

...PIDD1, ADNP, FANCD2, and RAD54L). The CUX1 variant is de novo, as are two cases who had mutations in genes that affect m...

NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cell…

Yap(JKY),Duszyc(K),Schroder(K) Mol Cell 2025-10-16

...PIDD1, and open questions that continue to challenge the field as we move toward greater understanding of this enigmatic...

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold…

Peintner(L),Dorstyn(L),Kumar(S),Aneichyk(T),… Cell Death Differ 2016-05-09

...PIDD1). As such, RAIDD has been implicated in DNA-damage-induced apoptosis as well as in tumorigenesis. As loss of Caspa...

PIDD4, a novel PIDD isoform without the LRR domain, can independently induce ce…

Huang(Lin),Han(Dingding),Yang(Xianmei),Qin(B… Biochem Biophys Res Commun 2011-05-31

PIDD1 (P53-induced death domain) is a pro-apoptotic gene which can be induced by p53. So far, three alternative splicing...

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