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The immature B-cell subpopulation with low RAG1 expression is increased in the …

Toda(T),Kitabatake(M),Igarashi(H),Sakaguchi(… Eur J Immunol 2009-02-00

...RAG1-GFP(-) and RAG1-GFP(+) subpopulations. The RAG1-GFP(-) immature B-cell population was in the minority in C57BL/6(RA...

RAG1 targeting in the genome is dominated by chromatin interactions mediated by…

Maman(Y),Teng(G),Seth(R),Kleinstein(SH),Scha… Nucleic Acids Res 2016-11-16

...RAG1-intrinsic mechanisms in determining RAG1 binding patterns is not known. Through analysis of deep RAG1 ChIP-seq data...

Mapping and Quantitation of the Interaction between the Recombination Activatin…

Zhang(YH),Shetty(K),Surleac(MD),Petrescu(AJ)… J Biol Chem 2015-05-08

...RAG1 necessary for interaction with RAG2 and to measure the RAG1-RAG2 binding affinity (KD ∼0.4 μM) (where RAG1 and RAG2...

Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal seque…

Akamatsu(Y),Oettinger(MA) Mol Cell Biol 1998-08-00

...RAG1 and RAG2 in signal recognition, we have compared the DNA binding activities of RAG1 alone and RAG1 plus RAG2 by gel...

RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination.

Gan(T),Wang(Y),Liu(Y),Schatz(DG),Hu(J) Cell Rep 2021-10-12

...RAG1 by RAG2. Therefore, we propose that RAG2 coevolves with RAG1 to release inert RAG1 from aggregates and thereby acti...

RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J re…

Deng(Z),Liu(H),Liu(X) Cell Res 2015-02-00

RAG1 and RAG2 proteins are key components in V(D)J recombination. The core region of RAG1 is capable of catalyzing the r...

Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.

Simkus(C),Makiya(M),Jones(JM) Mol Immunol 2009-04-00

...RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquityl...

RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute ly…

Han(Q),Ma(J),Gu(Y),Song(H),Kapadia(M),Kawasa… J Cancer 2019-00-00

...RAG1 promoter and suppression of RAG1 expression in primary ALL cells. Taken together, these results demonstrate that RA...

A Spontaneous RAG1 Nonsense Mutation Unveils Naturally Occurring N-Terminal Tru…

Burn(TN),Lee(KD),Dawany(N),Robertson(TF),Fis… Immunohorizons 2020-00-06

...RAG1 and RAG2 have been a focus of intense study for decades. To date, RAG1 has been studied as a single isoform; howeve...

Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing…

Dudley(DD),Sekiguchi(J),Zhu(C),Sadofsky(MJ),… J Exp Med 2003-11-03

...RAG1 in vivo, we generated core RAG1 knockin (RAG1(c/c)) mice. Significant B and T cell numbers are generated in RAG1(c/...

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