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PMID: 1068482 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Vitamin A-containing lipocytes and formation of type III collagen in liver injury.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 10 ·1976-10-00 ·Pages 3719-22

Kent G, Gay S, Inouye T, Bahu R, Minick OT, Popper H

Abstract

Hepatocellular necrosis in carbon tetracholride-induced injury of rats is associated with an accumulation of lipocytes (perisinusoidal cells or Ito cells) containing fat droplets and giving vitamin A fluorescence. In the subsequent formation of connective tissue septa, transitional cells having morphologic characteristics of lipocytes and fibroblasts are abundant and are associated with the appearance of type III collage-. The features suggest that the lipocyte is the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen. The process is a postulated link between hepatocellular necrosis and fibrosis.

MeSH Terms

Animals Carbon Tetrachloride Poisoning/metabolism,pathology Collagen/biosynthesis Fat Necrosis Fibroblasts/metabolism Liver/metabolism,pathology Rats Vitamin A/pharmacology

Chemicals

Vitamin A Collagen

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kent G

Gay S

Inouye T

Bahu R

Minick O T

Popper H

References (14)

14 references, click to expand

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The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury.
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Proc Natl Acad Sci U S A. 1976 Feb;73(2):539-43 PMID: 1061156
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.10.3719

Published

1976-10-00

Pages

3719-22

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC431190

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.10.3719 PMC Full Text View journal details

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Vitamin A-containing lipocytes and formation of type III collagen in liver injury.

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