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PMID: 1085337 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.

The Journal of experimental medicine ·Vol. 144 ·No. 3 ·1976-09-01 ·Pages 685-98

Okumura K, Herzenberg LA, Murphy DB, McDevitt HO, Herzenberg LA

Abstract

Data presented here show that locidentify in the I-region of the H-2 gene complex are selectively expressed in different functional T-cell subpopulations. These loci are closely linked (or possibly identical) to loci that control immune responses. They control surface determinants which identify helper and suppressor T lymphocytes. Determinants described here on allotype suppressor T cells (Ts) are found on normal (nonsuppressed) lymphoid cells, but are not found on helper T cells (Th). These determinants are controlled by a locus mapping in the I region of the H-2 complex. In an accompanying publication we show that this locus (Ia-4) marks a new I subregion (I-J) and is expressed only on T cells. Thus Ia-4 determinants idenfity a T-cell subpopulation which includes Ts but not Th. Th also carry identifying surface determinants controlled by loci that map to the H-2 complex, probably within the I region. These determinants are not found on Ts. Data presented also establish that loci in the I region control determinants on Th, but do not conclusively demonstrate that these are the determinants that distinguish Th from Ts. The selective expression of H-2-controlled determinants on Ts and Th suggests that these determinants are directly involved in immunoregulation.

MeSH Terms
Animals Antibody Formation B-Lymphocytes/immunology Chromosome Mapping Genes Genetic Linkage Histocompatibility Antigens Immunologic Memory Immunosuppression Therapy Isoantigens Mice T-Lymphocytes/immunology
Chemicals
Histocompatibility Antigens Isoantigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Okumura K
Herzenberg L A
Murphy D B
McDevitt H O
Herzenberg L A
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25 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.144.3.685
Published
1976-09-01
Pages
685-98
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2190396
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.144.3.685 PMC Full Text View journal details
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