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PMID: 10922039 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Genetic complexity of pathogen perception by plants: the example of Rcr3, a tomato gene required specifically by Cf-2.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 16 ·2000-08-01 ·Pages 8807-14

Dixon MS, Golstein C, Thomas CM, van Der Biezen EA, Jones JD

Abstract

Genetic analysis of plant-pathogen interactions has demonstrated that resistance to infection is often determined by the interaction of dominant plant resistance (R) genes and dominant pathogen-encoded avirulence (Avr) genes. It was postulated that R genes encode receptors for Avr determinants. A large number of R genes and their cognate Avr genes have now been analyzed at the molecular level. R gene loci are extremely polymorphic, particularly in sequences encoding amino acids of the leucine-rich repeat motif. A major challenge is to determine how Avr perception by R proteins triggers the plant defense response. Mutational analysis has identified several genes required for the function of specific R proteins. Here we report the identification of Rcr3, a tomato gene required specifically for Cf-2-mediated resistance. We propose that Avr products interact with host proteins to promote disease, and that R proteins "guard" these host components and initiate Avr-dependent plant defense responses.

MeSH Terms
Biological Evolution Chromosome Mapping Genes, Plant Lycopersicon esculentum/genetics,microbiology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dixon M S
The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom.
Golstein C
Thomas C M
van Der Biezen E A
Jones J D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.97.16.8807
Published
2000-08-01
Pages
8807-14
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC34016
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.97.16.8807 PMC Full Text View journal details
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