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PMID: 10941822 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Chemokines and dendritic cell traffic.

Journal of clinical immunology ·Vol. 20 ·No. 3 ·2000-05-00 ·Pages 151-60

Sozzani S, Allavena P, Vecchi A, Mantovani A

Abstract

Localization in tissues and migration to lymphoid organs are essential steps in the immunobiology of dendritic cells (DC). Chemokines play an important role in guiding the traffic of DC. Receptor expression and responsiveness to constitutively made chemokines account for the presence of DC in normal tissues. Inflammatory chemokines and nonchemokine attractants promote recruitment and localization of DC at sites of inflammation and infection. Upon exposure to maturation signals, DC undergo a chemokine receptor switch, with down-regulation of inflammatory chemokine receptors followed by induction of CCR7. These temporally coordinated events allow DC to leave tissues and to localize in lymphoid organs by responding to CCR7 agonists. DC are also present in tumors that produce chemokines, but their significance remains to be defined. In addition to responding to chemokines, DC are a major source of certain chemokines such as macrophage-derived chemokine. The interaction of DC with chemokines is essential to the function of these cells in normal and pathological conditions and may provide tools for novel therapeutic strategies.

MeSH Terms
Animals Cell Adhesion Molecules/immunology,physiology Cell Differentiation Cell Movement/immunology Chemokines/immunology,physiology Dendritic Cells/cytology,immunology,physiology Endothelium/cytology,immunology Humans Lymphoid Tissue/cytology,immunology Neoplasms/immunology,pathology
Chemicals
Cell Adhesion Molecules Chemokines
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sozzani S
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Allavena P
Vecchi A
Mantovani A
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1023/a:1006659211340
Published
2000-05-00
Pages
151-60
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1006659211340 View journal details
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