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PMID: 1127380 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Association of HL-A 5 and immune responsiveness in vitro to streptococcal antigens.

The Journal of experimental medicine ·Vol. 141 ·No. 5 ·1975-05-01 ·Pages 935-43

Greenberg LJ, Gray ED, Yunis EJ

Abstract

Lymphocytes, from randomly selected individuals having normal immune function, when incubated in vitro with varying concentrations of streptococcal antigens, responded in three ways: (a) response over the entire antigen concentration range, i.e., responders; (b) low response to only the highest antigen concentrations; and (c) no response at any antigen concentration. Frequency distribution analysis of these groups indicated that a significant association occurred between the ability to respond and HL-A 5.

MeSH Terms
Adult Aged Antigens, Bacterial HLA Antigens Histocompatibility Antigens Humans Immunogenetics Lymphocyte Activation Lymphocytes/immunology,metabolism Middle Aged Streptococcus/immunology Streptodornase and Streptokinase/immunology Thymidine/metabolism Tritium
Chemicals
Antigens, Bacterial HLA Antigens Histocompatibility Antigens Tritium Streptodornase and Streptokinase Thymidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Greenberg L J
Gray E D
Yunis E J
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27 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.141.5.935
Published
1975-05-01
Pages
935-43
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189789
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.141.5.935 PMC Full Text View journal details
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