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PMID: 11447263 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A role for CD36 in the regulation of dendritic cell function.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 15 ·2001-07-17 ·Pages 8750-5

Urban BC, Willcox N, Roberts DJ

Abstract

Dendritic cells (DC) are crucial for the induction of immune responses and thus an inviting target for modulation by pathogens. We have previously shown that Plasmodium falciparum-infected erythrocytes inhibit the maturation of DCs. Intact P. falciparum-infected erythrocytes can bind directly to CD36 and indirectly to CD51. It is striking that these receptors, at least in part, also mediate the phagocytosis of apoptotic cells. Here we show that antibodies against CD36 or CD51, as well as exposure to early apoptotic cells, profoundly modulate DC maturation and function in response to inflammatory signals. Although modulated DCs still secrete tumor necrosis factor-alpha, they fail to activate T cells and now secrete IL-10. We therefore propose that intact P. falciparum-infected erythrocytes and apoptotic cells engage similar pathways regulating DC function. These findings may have important consequences for the treatment of malaria and may suggest strategies for modulating pathological immune responses in autoimmune diseases.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antigens, CD/immunology Apoptosis/immunology CD36 Antigens/immunology Cell Differentiation Cells, Cultured Dendritic Cells/cytology,immunology,parasitology Humans Integrin alphaV Integrins/immunology Interleukin-10/metabolism Interleukin-12/metabolism Lymphocyte Activation/immunology Plasmodium falciparum/immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Antigens, CD CD36 Antigens Integrin alphaV Integrins Interleukin-10 Interleukin-12
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Urban B C
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. [email protected]
Willcox N
Roberts D J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.151028698
Email
[email protected]
Published
2001-07-17
Epub
2001-00-10
Pages
8750-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC37507
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.151028698 PMC Full Text View journal details
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