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PMID: 11459981 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 15 ·2001-07-17 ·Pages 8395-402

Davis L, Smith GR

Abstract

In most organisms homologous recombination is vital for the proper segregation of chromosomes during meiosis, the formation of haploid sex cells from diploid precursors. This review compares meiotic recombination and chromosome segregation in the fission yeast Schizosaccharomyces pombe and the distantly related budding yeast Saccharomyces cerevisiae, two especially tractable microorganisms. Certain features, such as the occurrence of DNA breaks associated with recombination, appear similar, suggesting that these features may be common in eukaryotes. Other features, such as the role of these breaks and the ability of chromosomes to segregate faithfully in the absence of recombination, appear different, suggesting multiple solutions to the problems faced in meiosis.

MeSH Terms
Animals Chromatids Chromosome Segregation DNA Damage DNA Replication DNA, Fungal Fungal Proteins/metabolism Gene Expression Regulation, Fungal Meiosis/physiology Recombination, Genetic Schizosaccharomyces/genetics,physiology Schizosaccharomyces pombe Proteins Synaptonemal Complex Trans-Activators
Chemicals
DNA, Fungal Fungal Proteins Schizosaccharomyces pombe Proteins Trans-Activators rep1 protein, S pombe
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Davis L
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, A1-162, Seattle, WA 98109-1024, USA.
Smith G R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.121005598
Published
2001-07-17
Pages
8395-402
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC37449
Subset
IM
Grants
NCI NIH HHS · T32 CA009437 · United States
NCI NIH HHS · T32 CA09437 · United States
NIGMS NIH HHS · GM31693 · United States
NIGMS NIH HHS · F32 GM20125 · United States
NIGMS NIH HHS · R01 GM031693 · United States
NIGMS NIH HHS · R56 GM031693 · United States
NIGMS NIH HHS · GM32194 · United States
NIGMS NIH HHS · R01 GM032194 · United States
NIGMS NIH HHS · F32 GM020125 · United States
External Links
PubMed source DOI: 10.1073/pnas.121005598 PMC Full Text View journal details
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