Home LiteratureArticle Details
PMID: 11756464 Published · ppublish English Journal Article Review

Specific tetraspanin functions.

The Journal of cell biology ·Vol. 155 ·No. 7 ·2001-12-24 ·Pages 1103-7

Hemler ME

Abstract

Relatively little attention has been given to the large family of abundantly expressed transmembrane proteins known as tetraspanins. Now, the importance of tetraspanins is strongly supported by emerging genetic evidence, coupled with new insights into the biochemistry and functions of tetraspanin protein complexes.

MeSH Terms
Animals Caenorhabditis elegans/physiology Humans Mammals Membrane Proteins/physiology Nerve Tissue Proteins/physiology Saccharomyces cerevisiae/physiology Tetraspanins
Chemicals
Membrane Proteins Nerve Tissue Proteins TSPAN2 protein, human Tetraspanins Tspan5 protein, mouse
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hemler M E
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
References (56)
56 references, click to expand
  1. Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2.
    J Virol. 2000 Apr;74(8):3642-9 PMID: 10729140
  2. Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions.
    J Cell Biol. 1998 May 4;141(3):791-804 PMID: 9566977
  3. Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98.
    Mol Biol Cell. 2001 Apr;12(4):809-20 PMID: 11294888
  4. Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis.
    Nat Genet. 2000 May;25(1):67-73 PMID: 10802659
  5. Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition.
    Biochem J. 2001 Apr 1;355(Pt 1):13-8 PMID: 11256943
  6. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.
    J Cell Biol. 2000 May 15;149(4):969-82 PMID: 10811835
  7. A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation.
    Science. 1996 Mar 29;271(5257):1867-70 PMID: 8596956
  8. Molecular characterization of peripherin-2 and rom-1 mutants responsible for digenic retinitis pigmentosa.
    J Biol Chem. 2001 Jun 22;276(25):22388-96 PMID: 11297544
  9. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.
    EMBO J. 1997 Jul 16;16(14):4217-25 PMID: 9250665
  10. CD63 associates with CD11/CD18 in large detergent-resistant complexes after translocation to the cell surface in human neutrophils.
    FEBS Lett. 2000 Mar 3;469(1):52-6 PMID: 10708755
  11. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice.
    Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10844-9 PMID: 9380722
  12. Severely reduced female fertility in CD9-deficient mice.
    Science. 2000 Jan 14;287(5451):319-21 PMID: 10634790
  13. Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling.
    J Cell Biol. 1999 Jul 26;146(2):477-92 PMID: 10427099
  14. Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice.
    J Immunol. 2000 Nov 1;165(9):5054-61 PMID: 11046035
  15. GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy.
    Biochemistry. 2001 May 29;40(21):6414-21 PMID: 11371204
  16. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.
    J Biol Chem. 2001 Apr 27;276(17):14329-37 PMID: 11278880
  17. Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells.
    J Biol Chem. 1995 Dec 15;270(50):29752-9 PMID: 8530366
  18. Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth.
    J Cell Sci. 2000 Jun;113 ( Pt 11):1871-82 PMID: 10806098
  19. Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.
    Mol Biol Cell. 2002 Jan;13(1):1-11 PMID: 11809818
  20. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins.
    Immunogenetics. 1994;39(4):249-56 PMID: 8119731
  21. Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins.
    J Biol Chem. 2001 Jul 6;276(27):25005-13 PMID: 11325968
  22. Tetraspanins.
    Cell Mol Life Sci. 2001 Aug;58(9):1189-205 PMID: 11577978
  23. Tetraspanins and malignancy.
    Expert Rev Mol Med. 2001 Jan 31;2001:1-17 PMID: 14987371
  24. Requirement of CD9 on the egg plasma membrane for fertilization.
    Science. 2000 Jan 14;287(5451):321-4 PMID: 10634791
  25. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
    Annu Rev Immunol. 1998;16:89-109 PMID: 9597125
  26. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151.
    J Biol Chem. 2000 Mar 31;275(13):9230-8 PMID: 10734060
  27. Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent.
    J Cell Biol. 2000 Jun 12;149(6):1289-96 PMID: 10851025
  28. Disulfide-mediated oligomerization of Peripherin/Rds and Rom-1 in photoreceptor disk membranes. Implications for photoreceptor outer segment morphogenesis and degeneration.
    J Biol Chem. 2000 Feb 25;275(8):5370-8 PMID: 10681511
  29. CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1.
    J Neurosci Res. 1996 Jan 1;43(1):12-31 PMID: 8838570
  30. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins.
    J Immunol. 2001 Nov 1;167(9):5115-21 PMID: 11673522
  31. Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts.
    J Immunol. 2000 Feb 1;164(3):1251-9 PMID: 10640738
  32. Binding of hepatitis C virus to CD81.
    Science. 1998 Oct 30;282(5390):938-41 PMID: 9794763
  33. The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation.
    J Cell Biol. 2000 Feb 7;148(3):591-602 PMID: 10662783
  34. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.
    Biochem J. 1999 May 15;340 ( Pt 1):103-11 PMID: 10229664
  35. The role of the peripherin/RDS gene in retinal dystrophies.
    Acta Anat (Basel). 1998;162(2-3):75-84 PMID: 9831753
  36. FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein.
    J Biol Chem. 2001 Feb 16;276(7):4853-62 PMID: 11087758
  37. CD81 regulates neuron-induced astrocyte cell-cycle exit.
    Mol Cell Neurosci. 2001 Mar;17(3):551-60 PMID: 11273649
  38. Normal lymphocyte development but delayed humoral immune response in CD81-null mice.
    J Exp Med. 1997 Apr 21;185(8):1505-10 PMID: 9126932
  39. Analysis of the CD151-alpha3beta1 integrin and CD151-tetraspanin interactions by mutagenesis.
    J Biol Chem. 2001 Nov 2;276(44):41165-74 PMID: 11479292
  40. Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.
    Mol Biol Cell. 2002 Mar;13(3):767-81 PMID: 11907260
  41. Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux.
    J Cell Biol. 2000 Nov 27;151(5):961-72 PMID: 11085999
  42. Tetraspanins in intercellular adhesion of polarized epithelial cells: spatial and functional relationship to integrins and cadherins.
    J Cell Sci. 2001 Feb;114(Pt 3):577-87 PMID: 11171326
  43. Integrin associated proteins.
    Curr Opin Cell Biol. 1998 Oct;10(5):578-85 PMID: 9818167
  44. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.
    Nat Genet. 2000 Feb;24(2):167-70 PMID: 10655063
  45. Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase.
    Biochem J. 2000 Nov 1;351 Pt 3:629-37 PMID: 11042117
  46. Development and degeneration of retina in rds mutant mice: light microscopy.
    J Comp Neurol. 1980 Nov 1;194(1):193-207 PMID: 7440795
  47. Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance.
    J Cell Biol. 1999 Aug 23;146(4):893-904 PMID: 10459022
  48. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.
    J Biol Chem. 2001 Nov 2;276(44):40545-54 PMID: 11504738
  49. The L6 membrane proteins--a new four-transmembrane superfamily.
    Protein Sci. 2000 Aug;9(8):1594-600 PMID: 10975581
  50. Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity.
    J Biol Chem. 2000 Jun 16;275(24):18284-90 PMID: 10749879
  51. Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts.
    J Biol Chem. 2001 Mar 16;276(11):7974-84 PMID: 11113129
  52. PLS1, a gene encoding a tetraspanin-like protein, is required for penetration of rice leaf by the fungal pathogen Magnaporthe grisea.
    Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6963-8 PMID: 11391010
  53. Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain.
    J Comp Neurol. 1998 Jul 6;396(3):366-80 PMID: 9624590
  54. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.
    Mol Cell Biol. 2000 Aug;20(15):5363-9 PMID: 10891477
  55. The tetraspanin superfamily in insects.
    Insect Mol Biol. 2000 Dec;9(6):581-90 PMID: 11122467
  56. Cell surface monkey CD9 antigen is a coreceptor that increases diphtheria toxin sensitivity and diphtheria toxin receptor affinity.
    J Biol Chem. 2000 Mar 10;275(10):6901-7 PMID: 10702250
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
Published
2001-12-24
Epub
2001-00-24
Pages
1103-7
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2199333
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]