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PMID: 11804576 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Immature frontal lobe contributions to cognitive control in children: evidence from fMRI.

Neuron ·Vol. 33 ·No. 2 ·2002-01-17 ·Pages 301-11

Bunge SA, Dudukovic NM, Thomason ME, Vaidya CJ, Gabrieli JD

Abstract

Event-related fMRI was employed to characterize differences in brain activation between children ages 8-12 and adults related to two forms of cognitive control: interference suppression and response inhibition. Children were more susceptible to interference and less able to inhibit inappropriate responses than were adults. Effective interference suppression in children was associated with prefrontal activation in the opposite hemisphere relative to adults. In contrast, effective response inhibition in children was associated with activation of posterior, but not prefrontal, regions activated by adults. Children failed to activate a region in right ventrolateral prefrontal cortex that was recruited for both types of cognitive control by adults. Thus, children exhibited immature prefrontal activation that varied according to the type of cognitive control required.

MeSH Terms
Adult Aging/physiology Brain/physiology Child Child Behavior Cognition/physiology Female Frontal Lobe/physiology Humans Magnetic Resonance Imaging Male Neural Inhibition/physiology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bunge Silvia A
Neurosciences Program, Stanford University, Stanford, CA 94305, USA. [email protected]
Dudukovic Nicole M
Thomason Moriah E
Vaidya Chandan J
Gabrieli John D E
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/s0896-6273(01)00583-9
Email
[email protected]
Published
2002-01-17
Pages
301-11
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC4535916
Subset
IM
Grants
NIMH NIH HHS · R01 MH061426 · United States
PHS HHS · 61426 · United States
External Links
PubMed source DOI: 10.1016/s0896-6273(01)00583-9 PMC Full Text View journal details
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