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PMID: 11850274 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mutator bacteria as a risk factor in treatment of infectious diseases.

Antimicrobial agents and chemotherapy ·Vol. 46 ·No. 3 ·2002-03-00 ·Pages 863-5

Giraud A, Matic I, Radman M, Fons M, Taddei F

Abstract

We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.

MeSH Terms
Alleles Animals Anti-Bacterial Agents/therapeutic use Bacterial Infections/genetics,microbiology Colony Count, Microbial Digestive System/microbiology Drug Resistance, Microbial Escherichia coli/drug effects,genetics Germ-Free Life Mice Mice, Inbred C3H Mutation/genetics Risk Factors
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Giraud Antoine
UEPSD-FBI, Bat 440-CRJ-Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France.
Matic Ivan
Radman Miroslav
Fons Michel
Taddei François
References (18)
18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.46.3.863-865.2002
Published
2002-03-00
Pages
863-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC127494
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.46.3.863-865.2002 PMC Full Text View journal details
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