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PMID: 1236869 Published · ppublish English Journal Article

Reference equine antisera to 33 human adenovirus types: homologous and heterologous titers.

Journal of clinical microbiology ·Vol. 1 ·No. 1 ·1975-01-00 ·Pages 65-74

Hierholzer JC, Gamble WC, Dowdle WR

Abstract

Equine antisera to human adenovirus types 1 to 33 were prepared and evaluated by hemagglutination-inhibition and serum neutralization tests. Detailed data on the potency and purity of the immunizing antigens were tabulated as one means of evaluating the antisera. Most of the 52 hemagglutination-inhibition and 25 serum neutralization major or minor heterotypic responses among the equine antisera were observed at similar levels in previous studies with rabbit antisera and appeared to represent genuine antigenic relationships among the human adenoviruses. Equine antisera to human adenoviruses 1 to 33 and a similarly packaged normal horse serum served as lots of fully tested sera for definitive typing of isolates and as reference standards for evaluating other antisera.

MeSH Terms
Adenoviridae/classification,immunology Animals Antibodies, Viral/analysis Antigens, Viral Cross Reactions Evaluation Studies as Topic Hemagglutination Inhibition Tests Horses/immunology Humans Immune Sera/analysis,standards Neutralization Tests Serotyping
Chemicals
Antibodies, Viral Antigens, Viral Immune Sera
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hierholzer J C
Gamble W C
Dowdle W R
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.1.1.65-74.1975
Published
1975-01-00
Pages
65-74
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC274943
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.1.1.65-74.1975 PMC Full Text View journal details
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