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PMID: 12879149 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.

Journal of molecular medicine (Berlin, Germany) ·Vol. 81 ·No. 8 ·2003-08-00 ·Pages 455-70

Donath MY, Størling J, Maedler K, Mandrup-Poulsen T

Abstract

Pancreatic islet beta-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or relative insulin deficiency. beta-cell death in type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes beta-cell death occurs as the combined consequence of increased circulating glucose and saturated fatty acids together with adipocyte secreted factors and chronic activation of the innate immune system. In both diabetes types intra-islet inflammatory mediators seem to trigger a final common pathway leading to beta-cell apoptosis. Therefore anti-inflammatory therapeutic approaches designed to block beta-cell apoptosis could be a significant new development in type 1 and 2 diabetes.

MeSH Terms
Adipocytes/metabolism Animals Apoptosis Autoimmunity Cytokines/biosynthesis,metabolism Diabetes Mellitus, Type 1/etiology,immunology,physiopathology Diabetes Mellitus, Type 2/etiology,immunology,physiopathology Glucose/metabolism Humans Immunity, Active Immunity, Innate Inflammation Mediators/physiology Insulin Resistance Islets of Langerhans/physiopathology
Chemicals
Cytokines Inflammation Mediators Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Donath Marc Y
Division of Endocrinology and Diabetes, University Hospital, 8091 Zurich, Switzerland. [email protected]
Størling Joachim
Maedler Kathrin
Mandrup-Poulsen Thomas
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Article Info
Journal
Journal of molecular medicine (Berlin, Germany)
Abbr.
J Mol Med (Berl)
ISSN
0946-2716
DOI
10.1007/s00109-003-0450-y
Email
[email protected]
Published
2003-08-00
Epub
2003-00-18
Pages
455-70
Language
English
Region
Germany
NLM ID
9504370
Subset
IM
External Links
PubMed source DOI: 10.1007/s00109-003-0450-y View journal details
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