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PMID: 12904407 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of the hypervirulent lineages of Neisseria meningitidis, the ST-8 and ST-11 complexes, by using monoclonal antibodies specific to NmeDI.

Journal of clinical microbiology ·Vol. 41 ·No. 8 ·2003-08-00 ·Pages 3873-6

Claus H, Weinand H, Frosch M, Vogel U

Abstract

Most cases of serogroup C meningococcal disease are caused by the clonal lineages ST-8 and ST-11. The gene encoding the putative restriction-modification system NmeDI is specific to these lineages. We report here a monoclonal antibody directed against the NmeDI endonuclease as a tool for their rapid and spe-cific identification.

MeSH Terms
Antibodies, Monoclonal Antibody Specificity Bacterial Typing Techniques Carrier State/microbiology Humans Neisseria meningitidis/classification,immunology,isolation & purification,pathogenicity Restriction Mapping Virulence
Chemicals
Antibodies, Monoclonal
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Claus Heike
Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Weinand Hanne
Frosch Matthias
Vogel Ulrich
References (9)
9 references, click to expand
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/JCM.41.8.3873-3876.2003
Published
2003-08-00
Pages
3873-6
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC179822
Subset
IM
External Links
PubMed source DOI: 10.1128/JCM.41.8.3873-3876.2003 PMC Full Text View journal details
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