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PMID: 1339256 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 5 ·1992-05-00 ·Pages 1005-12

Nikolich MP, Shoemaker NB, Salyers AA

Abstract

The ribosome protection type of tetracycline resistance (Tcr) has been found in a variety of bacterial species, but the only two classes described previously, Tet(M) and Tet(O), shared a high degree of amino acid sequence identity (greater than 75%). Thus, it appeared that this type of resistance emerged recently in evolution and spread among different species of bacteria by horizontal transmission. We obtained the DNA sequence of a Tcr gene from Bacteroides, a genus of gram-negative, obligately anaerobic bacteria that is phylogenetically distant from the diverse species in which tet(M) and tet(O) have been found. The Bacteroides Tcr gene defines a new class of ribosome protection resistance genes, Tet(Q), and has a deduced amino acid sequence that was only 40% identical to Tet(M) or Tet(O). Like tet(M) and tet(O), tet(Q) appears to have spread by horizontal transmission, but only within the Bacteroides group.

MeSH Terms
Amino Acid Sequence Bacteroides/genetics Genes, Bacterial Microbial Sensitivity Tests Molecular Sequence Data Ribosomes/drug effects Tetracycline Resistance/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nikolich M P
Department of Microbiology, University of Illinois, Urbana 61801.
Shoemaker N B
Salyers A A
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.5.1005
Published
1992-05-00
Pages
1005-12
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC188826
Subset
IM
Grants
NIAID NIH HHS · AI22383 · United States
Databases
GENBANK
L04217, L04218, L04219, L04220, L04221, L04222, L04223, L04224, L04225, X58717
External Links
PubMed source DOI: 10.1128/AAC.36.5.1005 PMC Full Text View journal details
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