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PMID: 1398958 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Effect of exogenous sialylation of the lipooligosaccharide of Neisseria gonorrhoeae on opsonophagocytosis.

Infection and immunity ·Vol. 60 ·No. 10 ·1992-10-00 ·Pages 4439-42

Kim JJ, Zhou D, Mandrell RE, Griffiss JM

Abstract

Serum-sensitive Neisseria gonorrhoeae strains become serum resistant when grown in the presence of a sialic acid precursor, cytidine monophospho-N-acetylneuraminic acid. We examined the abilities of human neutrophils to phagocytose sialylated and nonsialylated gonococci and observed a decrease in the complement-dependent phagocytosis of sialylated gonococci compared with that of nonsialylated gonococci (50.7 versus 25.9% survival at 30 min). This decrease in opsonophagocytosis after sialylation may contribute to the pathogenicity of gonococcal infections.

MeSH Terms
Humans Lipopolysaccharides/metabolism N-Acetylneuraminic Acid Neisseria gonorrhoeae/immunology,metabolism Neutrophils/immunology Phagocytosis Sialic Acids/metabolism
Chemicals
Lipopolysaccharides Sialic Acids lipid-linked oligosaccharides N-Acetylneuraminic Acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kim J J
Centre for Immunochemistry, University of California, San Francisco 94143.
Zhou D
Mandrell R E
Griffiss J M
References (17)
17 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.10.4439-4442.1992
Published
1992-10-00
Pages
4439-42
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257487
Subset
IM
Grants
NIAID NIH HHS · AI 21620 · United States
NIAID NIH HHS · AI 28871 · United States
External Links
PubMed source DOI: 10.1128/iai.60.10.4439-4442.1992 PMC Full Text View journal details
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