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PMID: 14506289 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 100 Suppl 2 ·2003-11-25 ·Pages 14587-92

Kroymann J, Donnerhacke S, Schnabelrauch D, Mitchell-Olds T

Abstract

Glucosinolate profiles differ among Arabidopsis thaliana ecotypes, caused by the composition of alleles at several glucosinolate biosynthetic loci. One of these, GS-Elong, harbors a family of methylthioalkylmalate synthase (MAM) genes that determine the side chain length of aliphatic glucosinolate structures. Fine mapping reveals that GS-Elong constitutes an insect resistance quantitative trait locus, caused by variation in glucosinolate profiles conferred by polymorphism of MAM alleles in this region. A sequence survey of randomly chosen ecotypes indicates that GS-Elong is highly variable among A. thaliana ecotypes: indel polymorphisms are frequent, as well as gene conversion events between gene copies arranged in tandem. Furthermore, statistical methods of molecular population genetics suggest that one of the genes, MAM2, is subject to balancing selection. This may be caused by ecological tradeoffs, i.e., by contrasting physiological effects of glucosinolates on generalist vs. specialist insects.

MeSH Terms
Animals Arabidopsis/enzymology,genetics,growth & development,parasitology Arabidopsis Proteins/genetics Ecosystem Evolution, Molecular Gene Conversion/genetics Genetic Variation Glucosinolates/genetics Immunity, Innate/genetics Molecular Sequence Data Moths/pathogenicity Oxo-Acid-Lyases/genetics Polymorphism, Genetic Quantitative Trait Loci Selection, Genetic
Chemicals
Arabidopsis Proteins Glucosinolates Oxo-Acid-Lyases methylthioalkylmalate synthase 1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kroymann Juergen
Department of Genetics and Evolution, Max Planck Institute for Chemical Ecology, Winzerlaer Strasse 10, 07745 Jena, Germany.
Donnerhacke Susanne
Schnabelrauch Domenica
Mitchell-Olds Thomas
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.1734046100
Published
2003-11-25
Epub
2003-00-23
Pages
14587-92
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC304123
Subset
IM
Databases
GENBANK
AJ486882, AJ486883, AJ486884, AJ486885, AJ486886, AJ486887, AJ486888, AJ486889, AJ486890, AJ486891, AJ486892, AJ486893, AJ486894, AJ486895, AJ486896, AJ486897, AJ486898, AJ486899, AJ486900, AJ486901, AJ486902, AJ486903, AJ486904, AJ486905, AJ486906, AJ486907, AJ486908, AJ486909, AJ486910, AJ486911, AJ486912, AJ486913, AJ486914, AJ486915, AJ486916, AJ486917, AJ486918, AJ486919, AJ486920, AJ486921, AJ486922, AJ486923, AJ486924, AJ486925, AJ486926, AJ486927, AJ486928, AJ486929, AJ486930, AJ486931, AJ486932, AJ486933, AJ486934, AJ486935, AJ486936, AJ486937, AJ486938, AJ486939, AJ486940, AJ486941, AJ486942, AJ486943, AJ486944, AJ486945, AJ486946, AJ486947, AJ486948, AJ486949, AJ486950, AJ486951, AJ486952, AJ486953
External Links
PubMed source DOI: 10.1073/pnas.1734046100 PMC Full Text View journal details
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