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PMID: 1465428 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The alternative sigma factor katF (rpoS) regulates Salmonella virulence.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 24 ·1992-12-15 ·Pages 11978-82

Fang FC, Libby SJ, Buchmeier NA, Loewen PC, Switala J, Harwood J, Guiney DG

Abstract

Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence.

Related Genes
appR csi2 katF rpoS spvB
MeSH Terms
Animals Base Sequence Catalase/genetics DNA Damage DNA Repair Gene Expression Regulation, Bacterial Genes, Bacterial Hydrogen-Ion Concentration Methyl Methanesulfonate/toxicity Mice Molecular Sequence Data Oligodeoxyribonucleotides/chemistry Polymerase Chain Reaction Salmonella Infections, Animal/microbiology Salmonella typhimurium/genetics,pathogenicity Sigma Factor/genetics
Chemicals
Oligodeoxyribonucleotides Sigma Factor Methyl Methanesulfonate Catalase
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Fang F C
Department of Medicine, University of California, San Diego 92103.
Libby S J
Buchmeier N A
Loewen P C
Switala J
Harwood J
Guiney D G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.24.11978
Published
1992-12-15
Pages
11978-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC50681
Subset
IM
Grants
NIAID NIH HHS · 5 T32 AI07036 · United States
NIADDK NIH HHS · AM35108 · United States
NIDDK NIH HHS · DK01408-05 · United States
External Links
PubMed source DOI: 10.1073/pnas.89.24.11978 PMC Full Text View journal details
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