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PMID: 14668409 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of misoriented sites on neutrality tests with outgroup.

Genetics ·Vol. 165 ·No. 3 ·2003-11-00 ·Pages 1619-22

Baudry E, Depaulis F

Abstract

Several neutrality tests use outgroups to infer the ancestral and derived states for polymorphism data. However, homoplasy can result in the incorrect inference of the derived variant. We show that empirically derived rates of misorientation strongly influence Fay and Wu's H-test, especially when the sample size is large.

MeSH Terms

Mutation Polymorphism, Genetic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Baudry Emmanuelle

Laboratoire d'Ecologie, Centre National de la Recherche Scientifique UMR 7625-EPHE, Université Pierre et Marie Curie, 75252 Paris 05, France.

Depaulis Frantz

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Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/165.3.1619

Published

2003-11-00

Pages

1619-22

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1462824

Subset

External Links

PubMed source DOI: 10.1093/genetics/165.3.1619 PMC Full Text View journal details

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