Characteristics of the multiplication cycle of pneumonia virus of mice (PVM).
A study of the multiplication of PVM in the mouse lung yielded evidence in support of the hypothesis that discrete cycles occur. The cycle is characterized by a latent period of about 15 hours, an incremental period of 10 to 15 hours and a total duration of 24 to 30 hours. The yield of virus per cycle is approximately 16-fold. A large proportion, approximately 90 per cent, of PVM is lost on intranasal inoculation and cannot be recovered from the lung. Of the virus which reaches the lung, almost all becomes non-infective within 12 hours even though a considerable amount retains the capacity to cause hemagglutination. During the incremental period infective virus appears as soon as any increase in hemagglutination is demonstrable.
16 references, click to expand
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A resistant variant of mumps virus; multiplication of the variant in the presence of inhibitory quantities of Friedländer bacillus polysaccharide.J Exp Med. 1949 Nov;90(5):393-407 PMID: 18143585
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The dependence of the pathological lesion upon the multiplication of pneumonia virus of mice (PVM); kinetic relation between the degree of viral multiplication and the extent of pneumonia.J Exp Med. 1951 Feb;93(2):139-50 PMID: 14803638
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STUDIES ON A LUNG TISSUE COMPONENT WHICH COMBINES WITH PNEUMONIA VIRUS OF MICE (PVM).J Exp Med. 1947 Oct 31;86(5):393-407 PMID: 19871686
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Further studies on the associative reactions of pneumonia virus of mice and influenza viruses; combination with various animal tissues and adsorbents.J Exp Med. 1950 Jan 1;91(1):53-64 PMID: 15395573
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A LATENT VIRUS IN NORMAL MICE CAPABLE OF PRODUCING PNEUMONIA IN ITS NATURAL HOST.J Exp Med. 1940 Feb 29;71(3):391-408 PMID: 19870970
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STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : I. THE PRECISION OF MEASUREMENTS IN VIVO OF THE VIRUS AND ANTIBODIES AGAINST IT.J Exp Med. 1946 Jan 1;83(1):25-42 PMID: 19871514
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STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : III. HEMAGGLUTINATION BY THE VIRUS; THE OCCURRENCE OF COMBINATION BETWEEN THE VIRUS AND A TISSUE SUBSTANCE.J Exp Med. 1946 Jan 31;83(2):105-32 PMID: 19871517
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Studies on host-virus interactions in the chick embryo-influenza virus system; development of infectivity, hemagglutination, and complement fixation activities during the first infectious cycle.J Exp Med. 1949 Jul;90(1):23-37 PMID: 18152337
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THE DEMONSTRATION OF ONE-STEP GROWTH CURVES OF INFLUENZA VIRUSES THROUGH THE BLOCKING EFFECT OF IRRADIATED VIRUS ON FURTHER INFECTION.J Exp Med. 1947 Oct 31;86(5):423-37 PMID: 19871688
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THE MODIFYING EFFECTS OF CERTAIN SUBSTANCES OF BACTERIAL ORIGIN ON THE COURSE OF INFECTION WITH PNEUMONIA VIRUS OF MICE (PVM).J Exp Med. 1947 May 31;85(6):623-46 PMID: 19871640
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The growth cycle of influenza virus A; a study of the relations between virus, soluble antigen and host cell in fertile eggs inoculated with influenza virus.Br J Exp Pathol. 1948 Oct;29(5):390-9 PMID: 18108407
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CENTRIFUGATION STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : THE RELATIVE SIZES OF FREE AND COMBINED VIRUS.J Exp Med. 1947 Jan 1;85(1):23-38 PMID: 19871597
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PROPERTIES OF PNEUMONIA VIRUS OF MICE (PVM) IN RELATION TO ITS STATE.J Exp Med. 1947 Jan 1;85(1):39-53 PMID: 19871598
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One-step growth curves of various strains of influenza A and B viruses and their inhibition by inactivated virus of the homologous type.J Exp Med. 1949 Mar;89(3):279-85 PMID: 18110882
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The associative reactions of pneumonia virus of mice and influenza viruses; the effects of pH and electrolytes upon virus-host cell combinations.J Exp Med. 1948 Dec;88(6):621-44 PMID: 18103399
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Therapy of infection with pneumonia virus of mice (PVM); effect of a polysaccharide on the multiplication cycles of the virus and on the course of the viral pneumonia.J Exp Med. 1951 Feb;93(2):161-71 PMID: 14803640
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