Home LiteratureArticle Details
PMID: 150305 Published · ppublish English Journal Article

Cross-Canada survey of susceptibility of Neisseria gonorrhoeae isolates to six antimicrobial agents.

Canadian Medical Association journal ·Vol. 119 ·No. 3 ·1978-08-12 ·Pages 223-8

Dillon JR, Eidus L, Diena BB

Abstract

The minimum inhibitory concentrations (MIC's) of penicillin, ampicillin, tetracycline, erythromycin, spectinomycin and sulfadiazine were determined for 732 isolates of Neisseria gonorrhoeae collected in 1973-74. Comparison of the results of this survey with data from other Canadian studies showed that the percentage of isolates resistant to tetracycline had not changed since 1966, but that the percentage of erythromycin-resistant isolates had decreased. After an initial increase in 1966 the percentage of penicillin-resistant isolates stabilized. Spectinomycin-resistant isolates were not found. Positive correlations were observed between the MICs of the antibiotics tested; the highest positive correlations were between penicillin and ampicillin and between penicillin and tetracycline. A positive correlation was also noted between penicillin resistance and increasing spectinomycin MICs. Finally, a significant seasonal variation in MICs was found, the trend being towards increasing MICs during the summer.

MeSH Terms
Anti-Bacterial Agents/pharmacology Canada Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects Penicillin Resistance Penicillins/pharmacology Regression Analysis Spectinomycin/pharmacology Sulfadiazine/pharmacology Tetracycline/pharmacology
Chemicals
Anti-Bacterial Agents Penicillins Sulfadiazine Spectinomycin Tetracycline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dillon J R
Eidus L
Diena B B
References (20)
20 references, click to expand
  1. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results.
    N Engl J Med. 1976 Jan 1;294(1):5-9 PMID: 127947
  2. Sensitivity of N. gonorrhoeae to antibiotics.
    Br J Vener Dis. 1961 Jun;37:145-57 PMID: 13741074
  3. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.
    J Bacteriol. 1963 Jun;85:1274-9 PMID: 14047217
  4. Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae.
    Antimicrob Agents Chemother. 1977 Mar;11(3):528-33 PMID: 404964
  5. In-vitro activity of twelve antibacterial agents against Neisseria gonorrhoeae.
    Lancet. 1970 Feb 7;1(7641):263-5 PMID: 4189291
  6. Penicillin resistance of gonococci in South Vietnam.
    Med J Aust. 1973 Sep 29;2(13):638-41 PMID: 4201950
  7. International symposium on gonorrhea.
    Can Med Assoc J. 1973 Nov 17;109(10):1043-50 PMID: 4202346
  8. Antibiotic resistance in Neisseria gonorrhoeae.
    Med Clin North Am. 1972 Sep;56(5):1133-44 PMID: 4262305
  9. Spectinomycin (Trobicin), a new antibiotic for the treatment of gonorrhea.
    Int J Clin Pharmacol. 1972 Jun;6(2):143-9 PMID: 4264335
  10. Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae.
    J Infect Dis. 1973 Sep;128(3):321-30 PMID: 4269625
  11. Treatment of gonorrheal urethritis with spectinomycin hydrochloride.
    Can Med Assoc J. 1974 Jan 19;110(2):173 passim PMID: 4272505
  12. Gonorrhea--diagnosis and treatment.
    Obstet Gynecol. 1972 Feb;39(2):274-85 PMID: 4621637
  13. Susceptibility of Neisseria gonorrhoeae to seven antibiotics in vitro.
    Can Med Assoc J. 1972 Nov 18;107(10):959-62 PMID: 4628259
  14. Single-dose aqueous procaine penicillin G therapy for gonorrhea: use of probenecid and cause of treatment failure.
    J Infect Dis. 1973 Apr;127(4):455-60 PMID: 4632882
  15. Development of resistance of gonococci to penicillin: an eight-year study.
    Can Med Assoc J. 1967 Jan 7;96(1):33-5 PMID: 4959611
  16. Sensitivity to penicillin of Neisseria gonorrhoeae. Relationship to the results of treatment.
    Br J Vener Dis. 1969 Jun;45(2):151-3 PMID: 4977824
  17. Sensitivity of Neisseria gonorrhoeae to penicillin and other antibiotics. Studies carried out in Toronto during the period 1961 to 1968.
    Br J Vener Dis. 1969 Sep;45(3):216-22 PMID: 4981351
  18. A study of the relationships between the sensitivities of Neisseria gonorrhoeae to sodium penicillin G, four semi-synthetic penicillins, spiramycin, and fusidic acid.
    Br J Vener Dis. 1968 Jun;44(2):140-50 PMID: 5005577
  19. Penicillinase-producing Neisseria gonorrhoeae.
    Lancet. 1976 Sep 25;2(7987):657-8 PMID: 60519
  20. Multiple antibiotic resistance in clinical strains of Neisseria gonorrhoeae isolated in South Carolina.
    Antimicrob Agents Chemother. 1976 Oct;10(4):639-45 PMID: 825034
Article Info
Journal
Canadian Medical Association journal
Abbr.
Can Med Assoc J
ISSN
0008-4409
Published
1978-08-12
Pages
223-8
Language
English
Region
Canada
NLM ID
0414110
PMCID
PMC1818148
Subset
IM
External Links
PubMed source PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2