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PMID: 15123810 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The diploid genome sequence of Candida albicans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 19 ·2004-05-11 ·Pages 7329-34

Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S

Abstract

We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.

MeSH Terms
Candida albicans/genetics Diploidy Genome, Fungal Heterozygote
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Jones Ted
Stanford Genome Technology Center, Palo Alto, CA 94304, USA.
Federspiel Nancy A
Chibana Hiroji
Dungan Jan
Kalman Sue
Magee B B
Newport George
Thorstenson Yvonne R
Agabian Nina
Magee P T
Davis Ronald W
Scherer Stewart
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0401648101
Published
2004-05-11
Epub
2004-00-03
Pages
7329-34
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC409918
Subset
IM
Grants
NIDCR NIH HHS · P01 DE 07946 · United States
NIDCR NIH HHS · P01 DE007946 · United States
NIDCR NIH HHS · DE 12302-02S2 · United States
NIDCR NIH HHS · R01 DE 12940 · United States
NIAID NIH HHS · R01 AI016567 · United States
NIAID NIH HHS · N01 AI 05406 · United States
NIAID NIH HHS · R01 AI 46351 · United States
NIAID NIH HHS · R01 AI046351 · United States
NIAID NIH HHS · R01 AI 16567 · United States
External Links
PubMed source DOI: 10.1073/pnas.0401648101 PMC Full Text View journal details
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