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PMID: 11248064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genomic evidence for a complete sexual cycle in Candida albicans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 6 ·2001-03-13 ·Pages 3249-53

Tzung KW, Williams RM, Scherer S, Federspiel N, Jones T, Hansen N, Bivolarevic V, Huizar L, Komp C, Surzycki R, Tamse R, Davis RW, Agabian N

Abstract

Candida albicans is a diploid fungus that has become a medically important opportunistic pathogen in immunocompromised individuals. We have sequenced the C. albicans genome to 10.4-fold coverage and performed a comparative genomic analysis between C. albicans and Saccharomyces cerevisiae with the objective of assessing whether Candida possesses a genetic repertoire that could support a complete sexual cycle. Analyzing over 500 genes important for sexual differentiation in S. cerevisiae, we find many homologues of genes that are implicated in the initiation of meiosis, chromosome recombination, and the formation of synaptonemal complexes. However, others are striking in their absence. C. albicans seems to have homologues of all of the elements of a functional pheromone response pathway involved in mating in S. cerevisiae but lacks many homologues of S. cerevisiae genes for meiosis. Other meiotic gene homologues in organisms ranging from filamentous fungi to Drosophila melanogaster and Caenorhabditis elegans were also found in the C. albicans genome, suggesting potential alternative mechanisms of genetic exchange.

MeSH Terms
Animals Candida albicans/cytology,genetics,metabolism,physiology Genome, Fungal Meiosis/physiology Morphogenesis Signal Transduction Spores, Fungal
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Tzung K W
Graduate Program in Oral Biology, Department of Stomatology, University of California, San Francisco, CA 94143-0422, USA.
Williams R M
Scherer S
Federspiel N
Jones T
Hansen N
Bivolarevic V
Huizar L
Komp C
Surzycki R
Tamse R
Davis R W
Agabian N
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.061628798
Published
2001-03-13
Pages
3249-53
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC30639
Subset
IM
Grants
NIDCR NIH HHS · P01DE07946 · United States
NIDCR NIH HHS · DE12302-02S2 · United States
NIDCR NIH HHS · P01 DE007946 · United States
NIDCR NIH HHS · R01DE12940-01 · United States
NHGRI NIH HHS · HG01633 · United States
External Links
PubMed source DOI: 10.1073/pnas.061628798 PMC Full Text View journal details
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