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PMID: 15164120 Published · ppublish English Journal Article Review

Role of infiltrated leucocytes in tumour growth and spread.

British journal of cancer ·Vol. 90 ·No. 11 ·2004-06-01 ·Pages 2053-8

Lin EY, Pollard JW

Abstract

Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.

MeSH Terms
Disease Progression Endopeptidases/biosynthesis,pharmacology Humans Leukocytes/physiology Lymphocytes, Tumor-Infiltrating/physiology Neoplasm Metastasis/physiopathology Neoplasms/blood supply,immunology,physiopathology Neovascularization, Pathologic
Chemicals
Endopeptidases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lin E Y
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women's Health,Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.
Pollard J W
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/sj.bjc.6601705
Published
2004-06-01
Pages
2053-8
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2410285
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjc.6601705 PMC Full Text View journal details
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