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PMID: 15170228 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Confirmation and dissection of QTL controlling resistance to malaria in mice.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 15 ·No. 5 ·2004-05-00 ·Pages 390-8

Hernandez-Valladares M, Naessens J, Gibson JP, Musoke AJ, Nagda S, Rihet P, Ole-MoiYoi OK, Iraqi FA

Abstract

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F(2) populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.

MeSH Terms
Animals Chromosome Mapping Chromosomes/genetics Crosses, Genetic Female Genetic Linkage Genotype Immunity, Innate Lod Score Malaria/genetics,immunology,parasitology Male Mice Mice, Inbred C57BL Microsatellite Repeats Phenotype Plasmodium chabaudi/pathogenicity Quantitative Trait Loci
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Hernandez-Valladares Maria
International Livestock Research Institute, Nairobi, Kenya.
Naessens Jan
Gibson John P
Musoke Anthony J
Nagda Sonal
Rihet Pascal
Ole-MoiYoi Onesmo K
Iraqi Fuad A
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/s00335-004-3042-4
Published
2004-05-00
Pages
390-8
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/s00335-004-3042-4 View journal details
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